Leptomycin B

Name: Leptomycin B
Brand: Tocris Bioscience
SKU: 1987

Cat. No. 1987 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1987 has been discontinued.

View all Translocation products.

说明： Inhibits nuclear export of proteins; antitumor

别名： CI 940,LMB

化学名： (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

说明书

引用文献 (4)

生物活性技术数据说明书参考文献

生物活性 for Leptomycin B

Leptomycin B is an antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo.

技术数据 for Leptomycin B

分子量	540.74
公式	C₃₃H₄₈O₆
储存	Desiccate at -20°C
CAS Number	87081-35-4
PubChem ID	57459335
InChI Key	YACHGFWEQXFSBS-RJXCBBHPSA-N
Smiles	CCC(\C=C\[C@@H]1OC(=O)C=C[C@@H]1C)=C/[C@H](C)C\C=C\C(C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Leptomycin B

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Leptomycin B

参考文献是支持产品生物活性的出版物。

Roberts et al (1986) In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI 940 and its hydroxy analog (PD 114,721). Cancer Chemother.Pharmacol. 16 95 PMID: 3081269

Wolff et al (1997) Leptomycin B is an inhibitor of nuclear export: inhibition of nucleocytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem.Biol. 4 139 PMID: 9190288

Freedman and Levine (1998) Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol.Cell.Biol. 18 7288 PMID: 9819415

Kudo et al (1998) Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp.Cell Res. 242 540 PMID: 9683540

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