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LDN 27219

Cat. No. 4602 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4602 has been discontinued.

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说明： Transglutaminase 2 (TG2) inhibitor; reversible
化学名： 2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]acetic acid hydrazide
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for LDN 27219

LDN 27219 is a transglutaminase 2 (TG2) inhibitor (IC50 = 0.25 μM). Binds at GTPase site; reversible.

化合物库 for LDN 27219

LDN 27219 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for LDN 27219

分子量 408.5
公式 C20H16N4O2S2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 312946-37-5
PubChem ID 1150683
InChI Key WLBUICQBNZXIDJ-UHFFFAOYSA-N
Smiles O=C(NN)CSC(N1C2=CC=CC=C2)=NC3=C(C(C4=CC=CC=C4)=CS3)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for LDN 27219

参考文献是支持产品生物活性的出版物。

Case and Stein (2007) Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry 46 1106 PMID: 17240993

Prime et al (2012) Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J.Med.Chem. 55 1021 PMID: 22224594

Duval et al (2005) Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorg.Med.Chem.Lett. 15 1885 PMID: 15780627

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关键词: LDN 27219, LDN 27219 supplier, LDN27219, transglutaminases, 2, TG2, TGase, tissue, tTG, inhibits, inhibitors, reversible, Other, Transferases, 4602, Tocris Bioscience

2 篇 LDN 27219 的引用文献

引用文献是使用了 Tocris 产品的出版物。 LDN 27219 的部分引用包括：

Yeo et al (2016) Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. Mediators Inflamm 5 PMID: 26956429

Harry T et al (2022) Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. J Clin Invest 132 PMID: 35499073

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