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Submit ReviewJTV 519 fumarate
说明： Ryanodine receptor (RyR) inhibitor
别名： K 201
化学名： 1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate
纯度： ≥97% (HPLC)
生物活性 for JTV 519 fumarate
JTV 519 fumarate is a ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.
技术数据 for JTV 519 fumarate
| 分子量 | 540.67 |
| 公式 | C25H32N2O2S.C4H4O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 1883549-36-7 |
| PubChem ID | 91826075 |
| InChI Key | ISLOBKLDZGDFTB-WLHGVMLRSA-N |
| Smiles | O=C(CCN3CCC(CC4=CC=CC=C4)CC3)N2CCSC1=CC=C(OC)C=C1C2.O=C(/C=C/C(O)=O)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for JTV 519 fumarate
参考文献 for JTV 519 fumarate
参考文献是支持产品生物活性的出版物。
Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID: 17313373
Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID: 17994112
Ye et al (2012) Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 81 53 PMID: 21989257
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关键词: JTV 519 fumarate, JTV 519 fumarate supplier, JTV519, fumarate, K201, ryanodine, receptors, inhibitors, inhibits, ryr1, ryr2, antiarrythmic, cardioprotective, K, 201, Ryanodine, Receptors, 4564, Tocris Bioscience
2 篇 JTV 519 fumarate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 JTV 519 fumarate 的部分引用包括：
Chih-Cheng et al (2021) ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain. Elife 10 PMID: 34569932
Andreia S et al (2023) Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells. Cell Rep Methods 3 100456 PMID: 37159667
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