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IU1-47

Cat. No. 6443 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6443 has been discontinued.

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说明： Potent USP14 inhibitor
化学名： 1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for IU1-47

IU1-47 is a potent USP14 inhibitor (IC50 = 60 nM). Demonstrates >30-fold selectivity for USP14 over USP5 (IsoT). Enhances degradation of proteasome substrates in vitro. Increases degradation of wild type and pathological tau in MEFs, primary neuronal cultures and human iPSC derived neurons.

技术数据 for IU1-47

分子量 330.85
公式 C19H23ClN2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 670270-31-2
PubChem ID 675477
InChI Key VXQIPRWKLACSKZ-UHFFFAOYSA-N
Smiles CC1=CC(C(CN2CCCCC2)=O)=C(N1C3=CC=C(C=C3)Cl)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for IU1-47

参考文献是支持产品生物活性的出版物。

Boselli et al (2017) An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J.Biol.Chem. 292 19209 PMID: 28972160

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关键词: IU1-47, IU1-47 supplier, USP14, inhibitors, inhibits, potent, tau, degradation, Deubiquitinating, Enzymes, 6443, Tocris Bioscience

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