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INF 39

Cat. No. 6341 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6341 has been discontinued.

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说明： Irreversible NLRP3 inhibitor
化学名： Ethyl 2-(2-chlorobenzyl)acrylate
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for INF 39

INF 39 is an irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity.

技术数据 for INF 39

分子量 224.68
公式 C12H13ClO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 866028-26-4
PubChem ID 69150705
InChI Key VTAOWWAFBSFWSG-UHFFFAOYSA-N
Smiles CCOC(C(CC1=C(C=CC=C1)Cl)=C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for INF 39

参考文献是支持产品生物活性的出版物。

Cocco et al (2017) Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease. J.Med.Chem. 60 3656 PMID: 28410442

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关键词: INF 39, INF 39 supplier, INF39, inflammasomes, NLRP3, NOD-like, receptors, inhibitors, inhibits, colitis, anti-inflammatory, pyroptosis, Inflammasomes, 6341, Tocris Bioscience

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