GaTx2

Pricing Availability   Qty
Cat.No. 4911 - GaTx2 | Val-Ser-Cys-Glu-Asp-Cys-Pro-Asp-His-Cys-Ser-Thr-Glu-Lys-Ala-Arg-Ala-Lys-Cys-Asp-Asn-Asp-Lys-Cys-Val-Cys-Glu-Pro-Ile | CAS No. 194665-85-5
说明: High affinity, selective ClC-2 blocker; inhibits slow-gating
别名: Leiuropeptide II
说明书
引用文献 (1)
评论

生物活性 for GaTx2

GaTx2 is a very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.

技术数据 for GaTx2

分子量 3192.54
公式 C125H199N39O47S6
序列 VSCEDCPDHCSTQKARAKCDNDKCVCEPI

(Modifications: Disulfide bridge: 3-19, 6-24, 10-26)

储存 Store at -20°C
CAS Number 194665-85-5
PubChem ID 90488986
InChI Key NDCNPIYRYDSDEM-TZZHORBYSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)[C@@H](C)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GaTx2

溶解性 Soluble to 1 mg/ml in water

产品说明书 for GaTx2

分析证书/产品说明书
选择另一批次:

参考文献 for GaTx2

参考文献是支持产品生物活性的出版物。

Schiffhauer et al (2013) Dual activation of CFTR and CLCN2 by lubipro. in murine nasal epithelia. Am.J.Physiol.Lung Cell Mol.Physiol. 304 L324 PMID: 23316067

Thompson et al (2009) Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J.Biol.Chem. 284 26051 PMID: 19574231


If you know of a relevant reference for GaTx2, please let us know.

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关键词: GaTx2, GaTx2 supplier, high, affinity, ClC-2, blockers, chloride, channels, selective, slow, gating, venoms, Leiuropeptide, II, Other, Chloride, Channels, 4911, Tocris Bioscience

1 篇 GaTx2 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GaTx2 的部分引用包括:

Nighot et al (2017) Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin. Exp Cell Res 352 113 PMID: 28161538


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