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Submit ReviewFenofibrate is a PPARα agonist; hypolipidemic. Attenuates insulin resistance and increases high-density lipoprotein-cholesterol in db/db mice.
Fenofibrate is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
分子量 | 360.83 |
公式 | C20H21ClO4 |
储存 | Store at RT |
纯度 | ≥99% (HPLC) |
CAS Number | 49562-28-9 |
PubChem ID | 3339 |
InChI Key | YMTINGFKWWXKFG-UHFFFAOYSA-N |
Smiles | CC(C)OC(C(C)(C)OC(C=C2)=CC=C2C(C1=CC=C(Cl)C=C1)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Mandard et al (2004) The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofi. treatment. J.Biol.Chem. 279 34411 PMID: 15190076
Park et al (2006) PPARα agonist fenofi. improves diabetic nephropathy in db/db mice. Kidney Int. 69 1511 PMID: 16672921
Balakumar et al (2011) Pleiotropic actions of fenofi. on the heart. Pharmacol.Res. 63 8 PMID: 21093591
关键词: Fenofibrate, Fenofibrate supplier, peroxisome, proliferator-activated, receptors, pparalpha, PPARa, PPARα, agonists, PPARalpha, Receptors, 4113, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Fenofibrate 的部分引用包括:
Lee et al (2018) Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency. J Clin Med 7 PMID: 30486372
Helmy et al (2015) Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs. PLoS One 10 e0142303 PMID: 26536032
Bumpus and Johnson (2011) 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated Invest Ophthalmol Vis Sci 339 886 PMID: 21896918
Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. J Pharmacol Exp Ther 10 e0120295 PMID: 25811180
Redlich et al (2014) Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections. PLoS One 11 108 PMID: 24927796
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