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Submit ReviewReported as active at the glycine site of the NMDA receptor but having little action at AMPA or kainate receptors.
分子量 | 231.04 |
储存 | Store at RT |
CAS Number | 25983-13-5 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Kleckner and Dingledine (1989) Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-MthD.-aspartate receptors. Mol.Pharmacol. 36 430 PMID: 2550776
Ogita et al (1990) 6,7-dichloroquinoxaline-2,3-dione is a competitive antagonist specific to the strychnine-insensitive [3H]glycine binding sites on the N-MthD.-aspartate receptor complex. J.Neurochem 54 699 PMID: 1967633
Yoneda and Ogita (1989) Abolition of the NMDA-mediated responses by a specific glycine antagonist, 6,7-dichloroquinoxaline-2,3-dione (DCQX). Biochem.Biophys.Res.Commun. 164 841 PMID: 2554902
关键词: DCQX, DCQX supplier, NMDA, Receptors, 0196, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.