Cystamine dihydrochloride

Name: Cystamine dihydrochloride
Brand: Tocris Bioscience
SKU: 4981

Cat. No. 4981 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4981 has been discontinued.

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说明： Transglutaminase inhibitor; neuroprotective

化学名： 2,2'-Diaminodiethyl disulfide dihydrochloride

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Cystamine dihydrochloride

Cystamine dihydrochloride is a transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.

技术数据 for Cystamine dihydrochloride

分子量	225.2
公式	C₄H₁₂N₂S₂.2HCl
储存	Desiccate at RT
CAS Number	56-17-7
PubChem ID	5941
InChI Key	YUFRRMZSSPQMOS-UHFFFAOYSA-N
Smiles	NCCSSCCN.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Cystamine dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cystamine dihydrochloride

参考文献是支持产品生物活性的出版物。

Borrell-Pages et al (2006) Cystamine and cyste. increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J.Clin.Invest. 116 1410 PMID: 16604191

Dedeoglu et al (2002) Therapeutic effects of cystamine in a murine model of Huntington's disease. J.Neurosci. 22 8942 PMID: 12388601

Mao et al (2006) Cystamine and cyste. prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells. Eur.J.Neurosci. 23 1701 PMID: 16623826

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关键词: Cystamine dihydrochloride, Cystamine dihydrochloride supplier, transglutaminase, TG, inhibitors, inhibits, neuroprotective, Huntingtons, Huntington's, disease, Other, Transferases, 4981, Tocris Bioscience

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