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Submit ReviewCGS 9343B
说明： Calmodulin antagonist
别名： Zaldaride maleate
化学名： 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
纯度： ≥98% (HPLC)
生物活性 for CGS 9343B
CGS 9343B is a calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.
技术数据 for CGS 9343B
| 分子量 | 544.61 |
| 公式 | C26H28N4O2.C4H4O4 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 109826-27-9 |
| PubChem ID | 6450522 |
| InChI Key | NGODOSILXOFQPH-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.CC1(CN2CCC(CC2)N2C(=O)NC3=C2C=CC=C3)OCC2=C(C=CC=C2)N2C=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CGS 9343B
参考文献 for CGS 9343B
参考文献是支持产品生物活性的出版物。
Norman et al (1987) CGS 9343B, a novel, potent, and selective inhibitor of Calmodulin activity. Mol.Pharmacol. 31 535 PMID: 3033469
Neuhaus and Reber (1992) Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur.J.Pharmacol. 226 183 PMID: 1379190
Li et al (2003) Calmodulin regulates the transcriptional activity of estrogen receptors. J.Biol.Chem. 278 1195 PMID: 12419798
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关键词: CGS 9343B, CGS 9343B supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, CGS9343B, Zaldaride, maleate, 2255, Tocris Bioscience
2 篇 CGS 9343B 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CGS 9343B 的部分引用包括：
Haag et al (2018) The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep 24 2418 PMID: 30157434
Hou et al (2015) The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Eur J Immunol 13 e1002233 PMID: 26334624
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