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CALP2

Cat. No. 2091 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2091 has been discontinued.

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说明： Cell-permeable calmodulin antagonist
别名： Calcium-like peptide 2
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生物活性 技术数据 说明书 参考文献

生物活性 for CALP2

Cell-permeable calmodulin (CaM) and troponin C antagonist; binds to the EF-hand/Ca2+-binding site. Inhibits Ca2+/CaM-dependent activation of phosphodiesterase. Increases agonist-induced intracellular [Ca2+] increases and NO production in airway epithelial cells and activates alveolar macrophages. Also inhibits VLA-5-mediated adhesion of mast cells to fibronectin.

技术数据 for CALP2

分子量 881.08
储存 Desiccate at -20°C
CAS Number 261969-05-5

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for CALP2

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化学品安全技术说明书

参考文献 for CALP2

参考文献是支持产品生物活性的出版物。

Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861 PMID: 11145661

Ten Broeke et al (2001) Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 15 1831 PMID: 11481245

Ten Broeke et al (2004) Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab.Invest. 84 29 PMID: 14631377

Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676

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关键词: CALP2, CALP2 supplier, Cell-permeable, calmodulin, (CaM), and, troponin, C, antagonist;, binds, to, the, EF-hand/Ca2+-binding, site., Inhibits, Ca2+/CaM-dependent, activation, of, phosphodiesterase., Increases, agonist-induced, intracellular, [Ca2+], increases, NO, production, in, airway, epithelial, cel, Calcium-like, peptide, 2, Calcium, Binding, Protein, 2091, Tocris Bioscience

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