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生物活性 for C 21
C 21 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 μM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1.
技术数据 for C 21
(Modifications: Ser-1 = N-terminal Ac, X = N5-(2-Chloro-1-iminoethyl)]-Orn)
|储存||Store at -20°C|
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for C 21
|溶解性||Soluble to 2 mg/ml in water|
参考文献 for C 21
Obianyo et al (2010) A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem 11 1219 PMID: 20480486
Obianyo and Thompson (2012) Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6). J.Biol.Chem. 287 6062 PMID: 22219200
If you know of a relevant reference for C 21, please let us know.
关键词: C 21, C 21 supplier, C21, selective, protein, arginine, methyltransferases, inhibitors, inhibits, PRMT1, epigenetics, histone, transferases, Protein, Arginine, Methyltransferases, 5128, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
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- Histone Methyltransferases