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BSJ-04-132

Cat. No. 6937 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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Cat.No. 6937 - BSJ-04-132 | C42H49N11O7
说明： Selective Cdk4 degrader
化学名： 7-Cyclopentyl-2-[[5-[4-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]oxy]acetamido]butyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethyl-7H-pyrrolo[2,3d]pyrimidine-6-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性

Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.

许可信息

Sold under license from Dana-Farber Cancer Institute

技术数据

分子量 819.92
公式 C42H49N11O7
储存 Store at -20°C
纯度 ≥98% (HPLC)
InChI Key GWLSXEHHNOBFOI-UHFFFAOYSA-N
Smiles O=C(COC1=C2C(C(N(C3C(NC(CC3)=O)=O)C2=O)=O)=CC=C1)NCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC7=C(C=C(C(N(C)C)=O)N7C8CCCC8)C=N6

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 81.99 100

制备储备液

以下数据基于产品分子量 819.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.22 mL 6.1 mL 12.2 mL
5 mM 0.24 mL 1.22 mL 2.44 mL
10 mM 0.12 mL 0.61 mL 1.22 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献

参考文献是支持产品生物活性的出版物。

Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID: 30802347

If you know of a relevant reference for BSJ-04-132, please let us know.

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关键词: BSJ-04-132, BSJ-04-132 supplier, cyclin, dependent, kinase, cdk4, degraders, degrades, selective, protac, proteolysis, targeting, chimera, Active, Degraders, Cyclin-dependent, Kinase, 6937, Tocris Bioscience

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