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说明： Potent and selective farnesyl transferase inhibitor
化学名： (3R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile
纯度： ≥99% (HPLC)
生物活性 for BMS 214662
Potent and selective farnesyl transferase inhibitor (IC50 = 1.35 nM). 1000-fold selective over GGT1 enzyme. Exhibits anti-tumour activity in vivo following oral administration.
许可信息
Sold with the permission of Bristol-Myers Squibb Company, subject to U.S. Patent No. 6,011,029 and other US and foreign patents.
技术数据 for BMS 214662
| 分子量 | 489.61 |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 195987-41-8 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BMS 214662
分析证书目前不在网上提供。
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参考文献 for BMS 214662
参考文献是支持产品生物活性的出版物。
Hunt et al (2000) Discovery of (R)-7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumour activity. J.Med.Chem. 43 3587 PMID: 11020273
Owa et al (2001) Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. Curr.Med.Chem. 8 1487 PMID: 11562278
Rose et al (2001) Preclinical antitumour activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor. Cancer Res. 61 7507 PMID: 11606387
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关键词: BMS 214662, BMS 214662 supplier, Other, Transferases, Post-translational, Modifications, 1444, Tocris Bioscience
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