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TT 232

Cat. No. 4639 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4639 has been discontinued.

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说明： sst1 and sst4 agonist
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for TT 232

TT 232 is a peptide agonist for sst1/sst4 somatostatin receptors. Somatostatin analog; inhibits tyrosine kinase activity in human colon tumor cell lines. Demonstrates an antiproliferative effect both in vitro and in vivo and induces apoptosis in a pancreatic tumor cell line. Does not inhibit growth hormone release or secretion.

技术数据 for TT 232

分子量 947.13
公式 C45H58N10O9S2
序列 fCYwKCT

(Modifications: Disulfide bridge between 2 - 6; Thr-7 = C-terminal amide)
储存 Store at -20°C
CAS Number 147159-51-1
PubChem ID 6918265
InChI Key SNAJPQVDGYDQSW-DYCFWDQMSA-N
Smiles [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for TT 232

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参考文献 for TT 232

参考文献是支持产品生物活性的出版物。

Tejeda et al (2006) Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models. Anticancer Res. 26 3477 PMID: 17094470

Kéri et al (1996) A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 93 12513 PMID: 8901613

Elekes et al (2008) Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 578 313 PMID: 17961545

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关键词: TT 232, TT 232 supplier, TT232, sst4, sst1, somatostatin, receptors, analogue, inhibits, tyrosine, kinase, antitumor, antiproliferative, apoptosis, Somatostatin, Receptors, 4639, Tocris Bioscience

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