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RO-275

Cat. No. 8977 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective HCN1 inhibitor
化学名： 4-((2-Chloro-3-methylpyridin-4-yl)ethynyl)-5-methyl-1-(pyridin-3-yl)-1H-imidazole-2-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RO-275

RO-275 is a potent and selective HCN1 (hyperpolarization-activated cyclic-nucleotide-gated channel 1) inhibitor (IC50 = 46 nM). It shows <100-fold selectivity over HCN2, HCN3 and HCN4. In vivo, RO-275 improves performance in a translationally relevant touchscreen task of working memory (TUNL) in rats. RO-275 is orally bioavailable and brain-penetrant.

许可信息

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the RO-275 probe summary on the SGC website.

技术数据 for RO-275

分子量 351.79
公式 C18H14ClN5O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2648837-04-9
PubChem ID 156441547
InChI Key STQKUEFQEVDNLU-UHFFFAOYSA-N
Smiles O=C(C1=NC(C#CC2=C(C)C(Cl)=NC=C2)=C(C)N1C3=CC=CN=C3)N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RO-275

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.59 50

制备储备液 for RO-275

以下数据基于产品分子量 351.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.69 mL 28.43 mL 56.85 mL
2.5 mM 1.14 mL 5.69 mL 11.37 mL
5 mM 0.57 mL 2.84 mL 5.69 mL
25 mM 0.11 mL 0.57 mL 1.14 mL

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参考文献 for RO-275

参考文献是支持产品生物活性的出版物。

Harde et al (2024) Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memory. Cell.Chem.Biol. 31 577 PMID: 38042151

If you know of a relevant reference for RO-275, please let us know.

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关键词: RO-275, RO-275 supplier, RO275, potent, selective, orally, bioavailable, brain-penetrant, inhibitors, inhibits, HCN1, HCN3, HCN4, working, memory, HCN, Channels, 8977, Tocris Bioscience

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