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RFRP 3 (human)

Cat. No. 4683 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4683 has been discontinued.

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说明： NPFF1 agonist; GnIH homolog
别名： Neuropeptide NPVF
纯度： ≥95% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for RFRP 3 (human)

RFRP 3 (human) is an agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.

技术数据 for RFRP 3 (human)

分子量 969.15
公式 C45H72N14O10
序列 VPNLPQRF

(Phe-8 = C-terminal amide)
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 311309-27-0
PubChem ID 71451611
InChI Key JFZCLMZUABKABL-GVCDGELBSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for RFRP 3 (human)

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参考文献 for RFRP 3 (human)

参考文献是支持产品生物活性的出版物。

Rizwan et al (2012) RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology 153 3770 PMID: 22691552

Ubuka et al (2009) Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One 4 e8400 PMID: 20027225

Hinuma et al (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell Biol. 2 703 PMID: 11025660

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关键词: RFRP 3 (human), RFRP 3 (human) supplier, RFamide-related, peptide, RFRP3, neuropeptide, FF/AF, agonists, gonadotropin-inhibitory, gonadotrophin-inhibitory, hormone, homologs, orthologs, GnIH, Neuropeptide, NPVF, Receptors, 4683, Tocris Bioscience

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