RF 9

Name: RF 9
Brand: Tocris Bioscience
SKU: 3672

Cat. No. 3672 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3672 has been discontinued.

View all Neuropeptide FF/AF Receptors products.

说明： Selective NPFF₁ and NPFF₂ antagonist

纯度： ≥95% (HPLC)

说明书

引用文献 (3)

生物活性技术数据说明书参考文献

生物活性 for RF 9

RF 9 is a selective NPFF receptor antagonist (K_i values are 58 and 75 nM at hNPFF₁ and hNPFF₂ receptors respectively). Displays selectivity over several related receptors including NPY Y₁ GPR10, GPR54, GPR103 and the opioid receptors. Blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo.

技术数据 for RF 9

分子量	482.62
公式	C₂₆H₃₈N₆O₃
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	876310-60-0
PubChem ID	53320361
InChI Key	UMKHUSRDQFQHAK-RNJMTYCLSA-N
Smiles	O=C(N[C@H]([C@](N[C@H](C(N)=O)CC4=CC=CC=C4)=O)CCCNC(N)=N)C1(CC(C3)C2)CC3CC2C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for RF 9

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RF 9

参考文献是支持产品生物活性的出版物。

Wang et al (2008) Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice. Peptides 29 1183 PMID: 18406009

Simonin et al (2006) RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc.Natl.Acad.Sci.USA 103 466

Fang et al (2008) Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist. Regul.Peptides 147 45

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关键词: RF 9, RF 9 supplier, Selective, NPFF1, NPFF2, antagonists, npffr1, npffr2, Neuropeptide, FF, AF, Receptors, FF/AF, RF9, neuropeptides, 3672, Tocris Bioscience