Iloprost

Pricing Availability   Qty
Cat.No. 2038 - Iloprost | C22H32O4 | CAS No. 78919-13-8
说明: Prostacyclin (PGI2) analog
别名: ZK 36374
化学名: (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoic acid
纯度: ≥97% (HPLC)
说明书
引用文献 (2)
评论
文献 (6)

生物活性 for Iloprost

Iloprost is a prostacyclin (PGI2) analog that binds with high affinity to IP, EP1 and EP3 receptors (Ki values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP1, EP3, EP4, FP, DP, EP2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC50 values are 0.24, 0.71 and 1.07 nM respectively).

技术数据 for Iloprost

分子量 360.49
公式 C22H32O4
储存 Desiccate at -20°C
纯度 ≥97% (HPLC)
CAS Number 78919-13-8
PubChem ID 5311181
InChI Key HIFJCPQKFCZDDL-ACWOEMLNSA-N
Smiles O[C@@H]1C[C@H]2[C@H](C/C(C2)=C/CCCC(O)=O)[C@H]1/C=C/[C@@H](O)C(C)CC#CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Iloprost

溶解性 Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml)

产品说明书 for Iloprost

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参考文献 for Iloprost

参考文献是支持产品生物活性的出版物。

Della Bella et al (2001) Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat. 65 73 PMID: 11403500

Abramovitz et al (2000) The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 1483 285 PMID: 10634944

Schror et al (1981) The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) - equipotent to PGI2 in vitro. Naunyn-Schmied.Arch.Pharmacol. 316 252


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关键词: Iloprost, Iloprost supplier, Prostacyclin, PGI2, IP, EP1, EP3, Receptors, Prostaglandin, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ZK36374, ZK, 36374, 2038, Tocris Bioscience

2 篇 Iloprost 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Iloprost 的部分引用包括:

Lee and Diamond (2015) A human platelet calcium calculator trained by pairwise agonist scanning. Nat Commun 11 e1004118 PMID: 25723389

Flamm et al (2012) Multiscale prediction of patient-specific platelet function under flow. Blood 120 190 PMID: 22517902


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