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Submit ReviewGPi 688
说明： Allosteric glycogen phosphorylase inhibitor
化学名： 2-Chloro-N-[1-[(2R)-2,3-dihydroxypropyl]-1,2,3,4-tetrahydro-2-oxo-3-quinolinyl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
纯度： ≥99% (HPLC)
生物活性 for GPi 688
GPi 688 is an allosteric glycogen phosphorylase inhibitor; acts at the indole site of glycogen phosphorylase. Inhibits glucagon-mediated hyperglycemia in vivo in the rat.
许可信息
Sold with the permission of AstraZeneca UK Ltd.
技术数据 for GPi 688
| 分子量 | 419.88 |
| 公式 | C19H18ClN3O4S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 918902-32-6 |
| PubChem ID | 10477191 |
| InChI Key | UICNBXVDHCBKCE-PUODRLBUSA-N |
| Smiles | OC[C@H](O)CN(C1=CC=CC=C1CC2NC(C3=CC4=C(SC(Cl)=C4)N3)=O)C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GPi 688
参考文献 for GPi 688
参考文献是支持产品生物活性的出版物。
Freeman et al (2006) Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme. Br.J.Pharmacol. 149 775 PMID: 17016495
Poucher et al (2007) An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia. Br.J.Pharmacol. 152 1239 PMID: 17934512
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关键词: GPi 688, GPi 688 supplier, GPi688, glycogen, phosphorylase, inhibitors, hyperglycaemia, hyperglycemia, inhibits, astrazeneca, Phosphorylases, 3967, Tocris Bioscience
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