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Submit ReviewG 28UCM
说明： FASN inhibitor
化学名： 3-(3,4,5-Trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate
纯度： ≥98% (HPLC)
生物活性 for G 28UCM
G 28UCM is a FASN inhibitor. Inhibits breast cancer cell proliferation in vitro (IC50 values are 21 - 79 μM), including cell lines resistant to anti-HER2 therapies. Blocks HER2 signaling and induces apoptosis. Inhibits growth of breast cancer xenografts in mice without causing anorexia.
技术数据 for G 28UCM
| 分子量 | 464.38 |
| 公式 | C24H16O10 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1094451-90-7 |
| PubChem ID | 24896615 |
| InChI Key | KJCWIWDPTNVWRX-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC(O)=C(O)C(O)=C3)OC2=CC(OC(C4=CC(O)=C(O)C(O)=C4)=O)=CC1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for G 28UCM
参考文献 for G 28UCM
参考文献是支持产品生物活性的出版物。
Puig et al (2011) A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 13 R131 PMID: 22177475
Puig et al (2009) Novel inhibitors of fatty acid synthase with anticancer activity. Clin.Cancer Res. 15 7608 PMID: 20008854
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关键词: G 28UCM, G 28UCM supplier, G28UCM, fatty, acid, synthase, inhibitors, inhibits, FASN, breast, cancer, Fatty, Acid, Synthase, 5446, Tocris Bioscience
1 篇 G 28UCM 的引用文献
引用文献是使用了 Tocris 产品的出版物。 G 28UCM 的部分引用包括：
Chu et al (2021) Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat.Metab. 3 1466 PMID: 34580494
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance