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说明： Potent EP4 receptor antagonist; orally bioavailable
化学名： (10S)-1'-[(3,5-Dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methylspiro[1H-imidazo[1,5-b][2]benzazepine-1,4'-piperidin]-3(2H)-one
纯度： ≥98% (HPLC)
生物活性 for ER 819762
ER 819762 is a potent EP4 receptor antagonist (IC50 = 59 nM). Suppresses EP4-mediated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells. Inhibits Th1 and Th17 cytokine production, suppresses collagen- and GPI-induced arthritis in mice. Attenuates CFA-induced inflammatory pain in rats. Analgesic. Orally bioavailable.
技术数据 for ER 819762
| 分子量 | 489.65 |
| 公式 | C30H39N3O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1155773-15-1 |
| PubChem ID | 42596951 |
| InChI Key | ANKFBAJRCGOKJJ-QFIPXVFZSA-N |
| Smiles | CCN1C(N2CC3=CC(OC)=CC(OC)=C3[C@H](C=C2C14CCN(CC4)CC5=CC(C)=CC(C)=C5)C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ER 819762
参考文献 for ER 819762
参考文献是支持产品生物活性的出版物。
Chen et al (2010) A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models. Br.J.Pharmacol. 160 292 PMID: 20423341
Jones et al (2016) Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2. Br.J.Pharmacol. 173 992 PMID: 26639895
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关键词: ER 819762, ER 819762 supplier, ER819762, potent, EP4, receptors, antagonists, prostanoids, PGE2, prostaglandins, high, affinity, orally, active, bioavailable, analgesics, arthritis, inflammatory, pain, inflammation, Prostanoid, Receptors, 5924, Tocris Bioscience
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