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Submit ReviewDH 97
说明： MT2 receptor antagonist
化学名： N-Pentanoyl-2-benzyltryptamine
生物活性 for DH 97
DH 97 is a relatively potent MT2 melatonin receptor antagonist (pKi value = 8.03), displaying 89- and 229-fold selectivity over MT1 and GPR50 (melatonin-related orphan receptor) respectively.
技术数据 for DH 97
| 分子量 | 334.46 |
| 公式 | C22H26N2O |
| 储存 | Store at RT |
| CAS Number | 220339-00-4 |
| PubChem ID | 3467177 |
| InChI Key | HDOIPCLEKCEANF-UHFFFAOYSA-N |
| Smiles | CCCCC(=O)NCCC1=C(CC2=CC=CC=C2)NC2=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DH 97
参考文献 for DH 97
参考文献是支持产品生物活性的出版物。
Teh and Sugden (1998) Comparison of the relationships of melatonin receptor agonists and antagonists; lengthening the N-acyl side chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch.Pharmacol. 358 522 PMID: 9840420
Ting et al (1999) Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br.J.Pharmacol. 127 987 PMID: 10433507
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关键词: DH 97, DH 97 supplier, MT2, receptor, antagonist, Receptors, Melatonin, DH97, (MT), 1218, Tocris Bioscience
2 篇 DH 97 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DH 97 的部分引用包括：
Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179 PMID: 21091649
Sjöblom et al (2003) Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes. BMC Neurosci 284 G1034 PMID: 12584110
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