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Submit ReviewCH 275
说明： Potent and selective sst1 agonist
生物活性 for CH 275
CH 275 is a potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens.
许可信息
Sold with the permission of the SALK Institute.
技术数据 for CH 275
| 分子量 | 1485.8 |
| 公式 | C74H96N14O15S2 |
| 序列 | CKFFWXTFTSC (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe) |
| 储存 | Store at -20°C |
| CAS Number | 174688-78-9 |
| PubChem ID | 90488765 |
| InChI Key | LFOPEPKKBBIGHF-RXUBGYFDSA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](NC(=O)[C@@H](CC2=CC=C(CNC(C)C)C=C2)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CH 275
参考文献 for CH 275
参考文献是支持产品生物活性的出版物。
Chen et al (1999) Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem.Biophys.Res.Commun. 258 689 PMID: 10329447
Rivier et al (2001) Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J.Med.Chem. 44 2238 PMID: 11405660
Vasilaki et al (2004) The somatostatin receptor (sst1) modulates the release of somatostatin in the nucleus accumbens of the rat. Neuropharmacology 47 612 PMID: 15380378
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关键词: CH 275, CH 275 supplier, CH275, supplier, somatostatin, receptor, 1, sst1, sstr1, agonists, potent, selective, nucleus, accumbens, Somatostatin, Receptors, 2454, Tocris Bioscience
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