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c-Di-AMP sodium salt

Cat. No. 5901 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Endogenous STING and DDX41 agonist; activates STING-dependent signaling
化学名： 3',5'-Cyclic diadenylic acid sodium salt
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for c-Di-AMP sodium salt

c-Di-AMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also A2A inverse agonist. Selectively induces apoptosis of monocytes in human PBMC cultures and in NSG mice transplanted with human CD34+ cells.

This product is sold in units of 702μg, equivalent to 1μmol.

技术数据 for c-Di-AMP sodium salt

分子量 702.38
公式 C20H22N10Na2O12P2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2734909-87-4
PubChem ID 11158091
InChI Key PDXMFTWFFKBFIN-XPWFQUROSA-N
Smiles O=P(O[C@H]1[C@H]([C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1CO4)O)(O[Na])OC[C@@H]5[C@H]([C@H]([C@H](N6C=NC7=C6N=CN=C7N)O5)O)OP4(O[Na])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for c-Di-AMP sodium salt

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参考文献 for c-Di-AMP sodium salt

参考文献是支持产品生物活性的出版物。

Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response. Nat.Immunol. 13 1155 PMID: 23142775

Tosolini et al (2015) Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Mol.Cell.Biol. 35 479 PMID: 25384972

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关键词: c-Di-AMP sodium salt, c-Di-AMP sodium salt supplier, STING, DDX41, ligands, activates, activators, adenosine, A2A, receptors, inverse, agonists, agonism, apoptosis, Adenosine, Receptors, STING-Dependent, Signaling, 5901, Tocris Bioscience

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Induction of type I IFNs with c-di-AMP in different cell lines.
By Anonymous on 08/19/2019
种属： Human

Induction of type I IFNs with c-di-AMP was studied in a variety ofcell lines. The human monocytic cell line THP-1 has been shown to expressall the CDSs4-6 with the exception of DAI.

Make sure to resuspend c-di-AMP and stimulate cells with 1-100 mg/ml c-di-AMP for 16-48 hours. <br /><br />Monitor induction of type I IFNs by measuring the levels of IRF-induced Lucia luciferase in the cell culture supernatant

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