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AZ'9567

Cat. No. 8897 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent MAT2a (methionine adenosyltransferase 2a) inhibitor
化学名： 3-Cyclopropyl-4-[4-(difluoromethoxy)phenyl]-1,4-dihydro-6-(2-methyl-2H-indazol-5-yl)-5H-pyrazolo[4,3-b]pyridin-5-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AZ'9567

AZ'9567 is a potent MAT2a (methionine adenosyltransferase 2a) inhibitor (IC50 = 1.3 nM). AZ'9567 shows strong antiproliferative effect on methylthioadenosine phosphorylase (MTAP) null lymphoma, lung, and pancreatic cancer cell lines and in vivo in MTAP KO HCT116 xenograft mouse model (20 mg/kg twice a day). AZ'9567 is orally bioavailable.

技术数据 for AZ'9567

分子量 447.45
公式 C24H19F2N5O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 3056570-19-2
PubChem ID 170995115
InChI Key QEASMQZYZCGOSA-UHFFFAOYSA-N
Smiles O=C1C(C2=CC3=CN(C)N=C3C=C2)=CC4=C(N1C5=CC=C(C=C5)OC(F)F)C(C6CC6)=NN4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZ'9567

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.74 100
ethanol 4.47 10

制备储备液 for AZ'9567

以下数据基于产品分子量 447.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.17 mL 22.35 mL
5 mM 0.45 mL 2.23 mL 4.47 mL
10 mM 0.22 mL 1.12 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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参考文献 for AZ'9567

参考文献是支持产品生物活性的出版物。

Atkinson et al (2024) Development of a series of pyrrolopyridone MAT2A inhibitors. J.Med.Chem. 67 4541 PMID: 38466661

If you know of a relevant reference for AZ'9567, please let us know.

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关键词: AZ''567, AZ''567 supplier, AZ9567, AZ-9567, potent, in, vivo, orally, bioavailable, MAT2a, MTAP, antitumor, cancer, methionine, adenosyltransferase, methylthioadenosine, phosphorylase, Other, Transferases, 8897, Tocris Bioscience

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