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Submit ReviewAMG 853
说明： Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist
化学名： 5-Chloro-4-[2-[[(2-chloro-4-cyclopropylphenyl)sulfonyl]amino]-4-[[(1,1-dimethylethyl)amino]carbonyl]phenoxy]-2-fluorobenzeneacetic acid
纯度： ≥98% (HPLC)
生物活性 for AMG 853
AMG 853 is a potent prostaglandin D2 (PGD2, CRTH2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Orally bioavailable.
技术数据 for AMG 853
| 分子量 | 609.49 |
| 公式 | C28H27Cl2FN2O6S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1169483-24-2 |
| PubChem ID | 42641863 |
| InChI Key | PFWVGKROPKKEDW-UHFFFAOYSA-N |
| Smiles | ClC1=CC(C2CC2)=CC=C1S(NC3=CC(C(NC(C)(C)C)=O)=CC=C3OC4=C(Cl)C=C(CC(O)=O)C(F)=C4)(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AMG 853
参考文献 for AMG 853
参考文献是支持产品生物活性的出版物。
Liu et al (2011) Discovery of AMG 853, a CRTH2 and DP dual antagonist. ACS Med.Chem.Lett. 2 326 PMID: 24900313
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关键词: AMG 853, AMG 853 supplier, AMG853, CRTH2, chemoattractant, receptor-homologous, molecule, expressed, on, Th2, cells, PGD2, prostaglandin, receptor, dual, antagonists, antagonism, orally, DP2, bioavailable, Prostanoid, Receptors, 5701, Tocris Bioscience
AMG 853 的评论
平均评分: 5 (Based on 1 Review.)
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AMG 853 blocks p38 phosphorylation in 15d-PGJ2 treated cardiomyocytes.
By
Chintan Koyani on 12/10/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： HL-1 cardiomyocytes
HL-1 cardiomyocytes were pre-incubated with AMG 853 (1 µM, 30 min) followed by treatment with 15d-PGJ2 (15 µM, 30 min) to follow p38 activation using Western blot analysis. AMG 853 inhibited 15d-induced p38 phosphorylation.
