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Category: EnzymesarrowKinasesarrowRho-kinases
Cat.No. Product Name
1254 Y-27632 dihydrochloride
Price and Availability

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Y-27632 dihydrochloride

Other Information:

Not for sale in Japan
Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecar boxamide dihydrochloride

Biological Activity:

Selective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and >250 μM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2. Smooth muscle relaxant and orally active in vivo.

Technical Data:

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M.Wt: 320.26
Formula: C14H21N3O.2HCl
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Phosphate buffered saline and to 100 mM in Water
Purity: >98%
CAS No: [146986-50-7]

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    References:

    Uehata et al (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase. Nature 389 990. Itoh et al (1998) An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nature Med. 5 221. Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. Narumiya et al (2000) Use and properties of ROCK-specific inhibitor Y-27632. Methods Enzymol. 325 273.
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    Keywords: Y-27632 Dihydrochloride, Kinases, Selective P160ROCK Inhibitor, Y27632 Dihydrochloride, Tocris Bioscience
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