Welcome to Tocris Bioscience

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Potent C5a receptor antagonist

3333 | NDT 9513727

IC₅₀ = 11.6 nM; selective for human C5aR (IC₅₀ for rat and mouse C5aR > 10 μM). Exhibits inverse agonist pharmacokinetics. Blocks degranulation response in C5a-stimulated U937 cells (IC₅₀ = 7.1 nM). Orally bioavailable.

Potent, reversible and selective FAAH inhibitor

4355 | TC-F 2

IC₅₀ values are 28 and 100 nM for human and rat FAAH respectively. Noncovalent inhibitor; displays selectivity for FAAH over cannabinoid-related targets (IC₅₀ > 20 μM for CB1, CB2 and VR1). Active in vivo.

Potent and selective S1P₁ receptor agonist

4363 | TC-SP 14

EC₅₀ values are 0.042 and 3.47 μM for human S1P₁ and S1P₃ respectively. Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.

Selective Na_V1.7 blocker

4435 | TC-N 1752

IC₅₀ values are 0.17, 0.3, 0.4 and 1.1 μM at hNa_V1.7, hNa_V1.3, hNa_V1.4 and hNa_V1.5 respectively. Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.

Potent and selective P2X₇ antagonist

4473 | A 804598

IC₅₀ values are 8.9 nM, 9.9 nM and 10.9 nM for mouse, rat and human P2X₇ receptors respectively. Selective for P2X₇ receptors (IC₅₀ > 5-10 μM for a wide array of cell surface receptors and ion channels assayed). Binds with high affinity (K_{i app} = 2.4 nM for rat P2X₇ receptors).

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EACR22 - The 22nd Biennial Congress of the EACR

July 7 - 10, 2012

Barcelona, Spain

Booth Number: C2