Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,500 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for October

Potent and selective IRAK4 inhibitor
5430 | AS 2444697

IC50 = 21 nM. Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNFα and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.

Related Products: Pirfenidone JTE 607 C 87
Potent and highly selective ROCK inhibitor
4961 | TC-S 7001

IC50 values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively. Exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. Reduces blood pressure in normotensive and hypertensive rats. Orally active.

Related Products: Y-27632 GSK 269962 OXA 06
Insulin degrading enzyme (IDE) inhibitor
5402 | 6bK

IC50 = 50 nM. Regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.

Related Products: Insulin BMS 536924 NBI 31772
Potent kynurenine 3-monooxygenase inhibitor
4926 | UPF 648

IC50 = 20 nM. Increases kynurenic acid levels, and decreases 3-HK and QUIN levels in cerebrum and liver of neonatal rodents. Neuroprotective in a Drosophila model of Huntington's disease.

Related Products: Ro 61-8048 P7C3 FRAX 486
Potent and selective JAK2 inhibitor
5617 | AZD 1480

IC50 < 3 nM. Exhibits >50-fold selectivity for JAK2 over JAK3. Exhibits antitumor effects and inhibits formation of lung metastases in a mouse renal cancer model. Also inhibits STAT3 signaling, tumor angiogenesis and myeloid cell migration in vivo.

Related Products: AG 490 Lestaurtinib NSC 33994

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com

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Bio-Techne Events

Pharmacology 2015

Pharmacology 2015

December 15 - 17, 2015

London UK