R&D Systems Inc. Tocris Bioscience Boston Biochem

Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,500 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for February

Potent Smoothened receptor agonist
4366 | SAG

Kd = 59 nM. Antagonizes cyclopamine action at the Smo receptor. Potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM); induces pathway activation independently of Ptch proteins. Enhances neuronal differentiation of iPSCs into dopaminergic neurons.

Related Products: Cyclopamine Purmorphamine 20(S)-Hydroxycholesterol
Potent and selective Iks channel blocker
5011 | HMR 1556

IC50 values are 10.5 and 34 nM in canine and guinea pig ventricular myocytes respectively. Selectively inhibits IKs currents over IKr, IKI, Ito and L-type calcium channel currents. Also has little or no effect on Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. Potentiates E-4031 -induced arrhythmias in vivo.

Related Products: E-4031 JNJ 303 BDS I
Potent and selective NUAK1/2 inhibitor
5177 | WZ 4003

IC50 values are 20 and 100 nM respectively. Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells.

Related Products: GSK 650394 RKI 1447 MRT 67307
Potent and selective Aurora kinase A inhibitor
5286 | TC-S 7010

IC50 = 3.4 nM. Exhibits 1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC50 values are 0.19 and 2.9 μM respectively).

Related Products: ZM 447439 Anacardic acid TC-A 2317
High affinity and selective activator of Bax
5314 | SMBA 1

Ki = 43.3 nM. Binds to the S184 binding pocket to block Bax phosphorylation. Does not bind to other Bcl-2 family members, including Bcl-2, Bak and Bid. Induces apoptosis in lung cancer cell lines expressing high levels of Bax. Represses tumor growth of A549 lung cancer xenografts in mice.

Related Products: AT 101 MIM1 BAM 7

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com/launch

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Bio-Techne Events

One Day Symposium

Bio-Techne Symposium 2015

Autophagy in Inflammatory Diseases and Cancer

March 17, 2015

Paris, France