R&D Systems Inc. Tocris Bioscience Boston Biochem

Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,500 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for April

Potent and selective DGAT-1 inhibitor
4837 | AZD 3988

IC50 = 0.6 nM. Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.

Related Products: CI 976 A 922500 (R)-(+)-Etomoxir sodium salt
Selective Mps1 kinase inhibitor
5142 | Mps1-IN-1

IC50 = 367 nM. Exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.

Related Products: AZ 3146 TC-S 7005 TC Mps1 12
Potent and selective BRPF1 inhibitor
5385 | GSK 5959

IC50 = 80 nM. Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3. Cell permeable.

Related Products: (+)-JQ1 I-BET 151 SGC-CBP30
Aquaporin 1 (AQP1) channel blocker
5412 | TC AQP1 1

IC50 = 8 μM. Inhibits water flux in Xenopus oocytes.

Related Products: ω-Conotoxin GVIA SNX 482 TGN 020
Inhibitor of TNF-α receptor 1 signaling
5432 | R 7050

Blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.

Related Products: SB 431542 YM 90709 AF 12198

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com

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Bio-Techne Events

DPG 2015

BNA 2015: Festival of Neuroscience

April 12 - 15, 2015

Edinburgh, UK

Booth: 25A