Welcome to Tocris Bioscience

Tocris provides the highest performing and most innovative range of research reagents available. Our range of over 3,000 products consists of small molecules, peptides and antibodies and is a unique collection of novel and exclusive tools for laboratory research.

High affinity and selective GPR30 antagonist

3678 | G-15

K_i = 20 nM. Displays no affinity for ERα and ERβ at concentrations up to 10 μM. Inhibits agonist-induced calcium mobilization in vitro (EC₅₀ of ~185 nM) and antagonizes the antidepressive effects of estrogen in vivo.

Selective Pim kinase inhibitor

3714 | TCS PIM-1 4a

IC₅₀ values are 24 and 100 nM for Pim-1 and Pim-2 respectively. Displays selectivity over a panel of ~50 other kinases tested. Exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro (IC₅₀ = 17 μM).

Selective mTOR inhibitor

3725 | KU 0063794

IC₅₀ ~10 nM for mTORC1 and mTORC2 respectively. Displays no activity at PI 3-K or 76 other kinases tested. Suppresses cell growth and induces G₁ cell cycle arrest in vitro.

Potent, collagenase-selective MMP inhibitor

2916 | Ro 32-3555

K_i values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively. Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.

Primes ESCs for differentiation

3741 | Stauprimide

Interacts with NME2 and inhibits its nuclear translocation. Increases the efficiency of directed differentiation of mouse and human embryonic stem cells (ESCs) in vitro.

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New 2009-10 Catalog!

Tocris' new catalog is out now. Packed-full of cutting edge products, request a copy or view PDF today.

Tocris Product News

Tocris Bioscience Awards Prize for Pharmacology Research

Chris Williams and Shaista Nisar, both PhD students at the University of Bristol, were selected as the best pharmacology research students of their year.