Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for February

Potent stearoyl-CoA desaturase 1 inhibitor
4845 | A 939572

IC50 = 0.4 nM. Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.

Related Products: STF 31 PluriSln 1 Wnt-C59
Potent and selective NHE1 inhibitor
5512 | BIX NHE1 inhibitor

IC50 = 31 nM. Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.

Related Products: KB-R7943 EIPA Cariporide
Potent and selective PERK inhibitor
5517 | AMG PERK 44

IC50 = 6 nM. Exhibits >160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable.

Related Products: GSK 2606414 trans-ISRIB Salubrinal
Selective BAZ2A and BAZ2B inhibitor
5635 | GSK 2801

IC50 values are 0.40 and 0.43 μM, respectively. Selective for BAZ2A/B over TAF1L and BRD9. Cell permeable and orally available.

Related Products: (+)-JQ1 I-CBP 112 PFI 4
Potent LRRK2 inhibitor; neuroprotective
5716 | PF 06447475

IC50 = 3 nM. Attenuates α-synuclein-induced dopaminergic neurodegeneration and neuroinflammation in G2019S-LRRK2 expressing rats. Also neuroprotective in wild type rats. Brain penetrant.

Related Products: LRRK2-IN-1 NQDI 1 GSK2578215A

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com

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Bio-Techne Events


The Society of Toxicology's 55th Annual Meeting and ToxExpo

March 14 - 16, 2016

New Orleans, LA, USA