R&D Systems Inc. Tocris Bioscience Boston Biochem

Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,500 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for March

Potent and selective EZH2/EZH1 inhibitor
4904 | UNC 1999

SAM-competitive EZH2/EZH1 lysine methyltransferase inhibitor (IC50 values are 2 and 45 nM respectively). Selective for EZH2/EZH1 over a panel of other methyltransferases and non-epigenetic targets. Reduces H3K27me3 levels in vitro. Prolongs survival of MLL-AF9 bearing mice. Orally bioavailable.

Related Products: UNC 0224 (R)-PFI 2 UNC 0642
Potent and selective ITK inhibitor
5009 | BMS 509744

IC50 = 19 nM. Displays 200-fold selectivity over Tec family kinases and 55-fold selectivity over other kinases tested. Decreases HIV infection of primary CD4+ T cells and attenuates the establishment of HIV infection in vitro. Reduces T cell proliferation and IL-2 production in vitro. Attenuates lung inflammation in a mouse model of ovalbumin-induced allergy/asthma.

Related Products: Maraviroc FC 131 PF 06465469
PFKFB3 inhibitor; antiangiogenic
5121 | 3PO

Reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro. Suppresses vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockers.

Related Products: CHC YZ9 GSK 2837808A
USP10 and USP13 inhibitor
5197 | Spautin 1

IC50 values are 0.6 and 0.7 μM respectively. Inhibitor of autophagy and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.

Related Products: HBX 41108 NSC 687852 P005091
Potent and selective MAGL inhibitor
5206 | JJKK 048

IC50 = 0.4 nM. Exhibits >13,000 and ~630-fold selectivity for MAGL over FAAH and ABHD6 respectively.

Related Products: JZL 184 KML 29 JW 642

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com

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Bio-Techne Events

AACR 2015

AACR 2015

April 18 - 22, 2015

Philadelphia, PA

Booth: 2135