R&D Systems Inc. Tocris Bioscience Boston Biochem

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The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuardorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for May

Potent C5a receptor antagonist
3333 | NDT 9513727

IC50 = 11.6 nM; selective for human C5aR (IC50 for rat and mouse C5aR > 10 μM). Exhibits inverse agonist pharmacokinetics. Blocks degranulation response in C5a-stimulated U937 cells (IC50 = 7.1 nM). Orally bioavailable.

Related Products: Clobenpropit Compstatin Compstatin control peptide
Potent, reversible and selective FAAH inhibitor
4355 | TC-F 2

IC50 values are 28 and 100 nM for human and rat FAAH respectively. Noncovalent inhibitor; displays selectivity for FAAH over cannabinoid-related targets (IC50 > 20 μM for CB1, CB2 and VR1). Active in vivo.

Related Products: AACOCF3 JNJ 1661010 PF 3845
Potent and selective S1P1 receptor agonist
4363 | TC-SP 14

EC50 values are 0.042 and 3.47 μM for human S1P1 and S1P3 respectively. Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.

Related Products: CYM 5442 Sphingosine-1-phosphate JTE 013
Selective NaV1.7 blocker
4435 | TC-N 1752

IC50 values are 0.17, 0.3, 0.4 and 1.1 μM at hNaV1.7, hNaV1.3, hNaV1.4 and hNaV1.5 respectively. Also inhibits tetrodotoxin-sensitive sodium channels. Displays analgesic efficacy in the formalin pain model.

Related Products: ProTx II QX 314 chloride Tetrodotoxin citrate
Potent and selective P2X7 antagonist
4473 | A 804598

IC50 values are 8.9 nM, 9.9 nM and 10.9 nM for mouse, rat and human P2X7 receptors respectively. Selective for P2X7 receptors (IC50 > 5-10 μM for a wide array of cell surface receptors and ion channels assayed). Binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors).

Related Products: BzATP triethylammonium salt A 438079 PF 477736

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New Product Guide

NPG

Highlights over 250 new products added in 2011/12. Request a copy or view PDF today.

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Tocris Events

Win a Kindle

EACR22

EACR22 - The 22nd Biennial Congress of the EACR

July 7 - 10, 2012

Barcelona, Spain

Booth Number: C2