Welcome to Tocris Bioscience
The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for February
IC50 = 0.4 nM. Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.Related Products: STF 31 PluriSln 1 Wnt-C59
IC50 = 31 nM. Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.Related Products: KB-R7943 EIPA Cariporide
IC50 = 6 nM. Exhibits >160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable.Related Products: GSK 2606414 trans-ISRIB Salubrinal
IC50 values are 0.40 and 0.43 μM, respectively. Selective for BAZ2A/B over TAF1L and BRD9. Cell permeable and orally available.Related Products: (+)-JQ1 I-CBP 112 PFI 4
IC50 = 3 nM. Attenuates α-synuclein-induced dopaminergic neurodegeneration and neuroinflammation in G2019S-LRRK2 expressing rats. Also neuroprotective in wild type rats. Brain penetrant.Related Products: LRRK2-IN-1 NQDI 1 GSK2578215A
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We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for AACR 2016.