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Tocris provides the highest performing and most innovative range of research reagents available. Our range of over 3,000 products consists of small molecules, peptides and antibodies and is a unique collection of novel and exclusive tools for laboratory research.

Dynamin inhibitor

3982 | Mdivi 1

IC₅₀ = 1 - 10 μM. Attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis.

Hsp70 inhibitor

3803 | VER 155008

IC₅₀ = 0.5 μM. Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78; selective against Hsp90β.

Positive allosteric modulator of mGlu₂

3949 | CBiPES

IC₅₀ = 98.2 nM. Mimics the action of LY 379268 (Cat. No. 2453); attenuates ketamine-evoked histamine release in vivo.

Potent γ-secretase inhibitor

2870 | BMS 299897

IC₅₀ = 12 nM. Inhibits Aβ40 and Aβ42 formation in vitro (IC₅₀ values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.

α5-selective GABA_A inverse agonist

3817 | MRK 016

EC₅₀ = 3 nM. Exhibits affinity at benzodiazepine binding site of recombinant human GABA_A receptors (K_i values are 0.77 nM, 0.83 nM, 0.85 nM and 1.4 nM for α3-, α1-, α2-, and α5-containing respectively). Increases long-term potentiation (LTP) in mouse hippocampal slices. Exhibits no anxiogenic or proconvulsant activity.

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Tocris partners with Jena Bioscience

Jena Bioscience products are now available from Tocris USA. View the Jena range here.

New Product Guide

Highlights over 250 new products added in 2009/10. Request a copy or view PDF today.