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The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for December
Inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively).Related Products: AMD 3100 octahydrochloride TC 14012 SB 265610
Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.Related Products: SB 590885 L-779,450 GDC 0879
Competitive inhibitor of the p53-MDM2/MDMX interaction (Kd = 493 nM for MDM2). Kills tumor cells in a p53-dependent manner.Related Products: Nutlin-3 RITA NSC 66811
IC50 values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively. Exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, MEK, ERK, c-Raf and c-Src. Orally bioavailable.Related Products: CID 2011756 CID 755673 kb NB 142-70
Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively; IC50 = 33 nM for TNKS2. Devoid of activity at PARP1 and PARP2 (IC50 >19 μM). Inhibits Wnt signaling and stabilizes Axin2 levels.Related Products: PJ 34 XAV 939 BYK 204165
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