Welcome to Tocris Bioscience

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Selective D₃ antagonist

4207 | SB 277011A

pK_i values are 8.0, 6.0, 5.0 and <5.2 for D₃, D₂, 5-HT_1D and 5-HT_1B respectively. Brain penetrant.

Specific E3 ubiquitin ligase inhibitor

4375 | SMER 3

Specific inhibitor of a yeast SCF family E3 ubiquitin ligase (SCF^Met30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of Rapamycin (Cat. No. 1292).

Potent and selective DAPK1 inhibitor

4301 | TC-DAPK 6

ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC₅₀ values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC₅₀ > 10 μM).

mGlu₅ antagonist

4394 | VU 0360223

Potent antagonist of mGlu₅ (IC₅₀ = 61 nM). Displays no activity at mGlu_1-4 and mGlu_7-8.

N-WASP inhibitor

4434 | Wiskostatin

Inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP₂-induced actin polymerization (EC₅₀ ~ 4μM).

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