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The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for December
Accelerates FRAP recovery of BRD4 and CREBBP in cells at a concentration of 1 μM.Related Products: (+)-JQ1 SGC-CBP30 I-CBP 112
IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively. Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Exhibits antithrombotic activity.Related Products: AS 252424 GSK 1059615 CZC 24832
Displays an orange intracellular fluorescence in response to H2O2 signals produced in RAW 264.7 macrophages and A431 cells during immune response and growth factor stimulation, respectively. Cell permeable.Related Products: FURA-2AM MitoPY1 CRANAD 2
EC50 = 0.5 nM. Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.Related Products: IWP 2 (R)-(+)-Etomoxir sodium salt Tocriscreen Stem Cell Toolbox
IC50 = 0.9 nM. Displays no effect at ASIC1b, ASIC2a, ASIC3, heteromeric ASIC channels, ENaC and KV2.1/2.2/4.2/4.3 channels expressed in oocytes, at concentrations up to 100 nM. Displays potent analgesic properties.Related Products: Amiloride Neuropeptide SF (mouse, rat) APETx2
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Potent, selective LRRK2 inhibitor
Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.