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The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for March
Selective for PLK2 over PLK3 and PLK1 (IC50 values are 4, 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.Related Products: GW 843682X SBE 13 Wortmannin
Exhibits greater potency than Niacin in a whole cell HTRF-cAMP assay (EC50 values are 12.9 and 51 nM respectively). Exhibits no binding at the GRP109B receptor. Shown to lower plasma free fatty acid levels in humans.Related Products: 3,5-DHBA LUF 6283
Exhibits potent inhibition of human, mouse and rat MAGL (IC50 values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC50 > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50 = 2.5 nM and >50 μM for 2-AG and AEA respectively).Related Products: JW 642 JZL 184 JZL 195
Kb values are 41 and 560 nM for OX1 and OX2 receptors respectively. Elicits anxiolytic effects in vivo. Brain penetrant and orally available.Related Products: OXA (17-33) SB 334867 SB 674042
Kd values are 1.8 and 3.1 μM respectively. Activates AMPK and PPARα signaling; ameliorates insulin resistance, dyslipidemia and glucose intolerance in db/db mice. Orally active antidiabetic agent.Related Products: GW 7647 Metformin Pioglitazone
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