Welcome to Tocris Bioscience

Tocris provides the highest performing and most innovative range of research reagents available. Our range of over 3,000 products consists of small molecules, peptides and antibodies and is a unique collection of novel and exclusive tools for laboratory research.

Subtype-selective α4β2 partial agonist

3754 | Varenicline

K_i values are 0.06, 240, 322 and 3540 nM for α4β2, α3β4, α7, α1βγδ receptors respectively. Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo.

Potent VEGFR, PDGFRβ and KIT inhibitor

3768 | Sunitinib

K_i values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively. Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.

Potent, selective CB₂ agonist

3556 | SER 601

K_i values are 6.3 nM and 1.2 μM for CB₂ and CB₁ receptors respectively. Displays analgesic activity in the formalin test in mice.

Potent and selective P2Y₁₂ antagonist

3321 | AR-C 66096

Blocks ADP-induced inhibition of adenylyl cyclase in vitro (PK_B =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC₅₀ = 8.16).

Dual CK1/cdk inhibitor

3610 | (R)-DRF053

IC₅₀ values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively. Selective over GSK-3 α/β (IC₅₀= 4.1 μM). Also shown to inhibit amyloid-β production in N2A-APP₆₉₅ cells.

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New 2009-10 Catalog!

Tocris' new catalog is out now. Packed-full of cutting edge products, request a copy or view PDF today.

Tocris Events

Meet your representative

AACR Annual Meeting 2010

17 - 21st April, 2010

Washington, DC

Booth No. 134