Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,500 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for July

Potent TLR7 agonist
4809 | DSR 6434

EC50 = 7.2 nM. Activates several immune effector cells in vitro. Suppresses metastasis in vivo and enhances efficacy of radiation therapy in a model of colorectal carcinoma.

Related Products: RWJ 21757 Imiquimod Resiquimod
Potent and selective PDGFR family inhibitor
5013 | AC 710

IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα. Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.

Related Products: DMPQ SU 16f Toceranib
High affinity and selective WDR5 antagonist
5267 | OICR 9429

WD repeat-containing protein 5 (WDR5) antagonist (Kd = 24-52 nM), Disrupts WDR5 interaction with MLL and H3 with >100-fold selectivity over other methyltransferases tested. Also disrupts MLL1-RbBP5 in vitro.

Related Products: Furamidine MM 102 WDR5 0103
Potent and selective ERK5 inhibitor
5393 | ERK5-IN-1

Inhibits EGFR-induced ERK5 autophosphorylation (EC50 = 90 nM) and ERK5 enzymatic activity (IC50 = 162 nM). Exhibits at least 30-fold selectivity for ERK5 over LRRK2 in a cell based assay. Also selective for ERK5 over a panel of other kinases. Orally bioavailable.

Related Products: FR 180204 XMD 8-92 BIX 02189
Potent C5a receptor antagonist
5473 | PMX 53

IC50 = 20 nM. Also MrgX2 agonist. Stimulates MrgX2-mediated mast cell degranulation. Also inhibits C5a-induced hypernociception in rats.

Related Products: Compstatin NDT 9513727 PMX 205

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com

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Bio-Techne Events

IBRO 2015

IBRO 2015

July 7 - 11, 2015

Rio de Janeiro, Brazil

Booth: B21