Welcome to Tocris Bioscience
The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
Featured Products
New for June
Potent Abl kinase inhibitor
4730 | PPY A
Inhibits T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.
Related Products: Bosutinib AP 24534 GNF 2Selective H4 agonist
4769 | VUF 10460
Displays 50-fold selectivity for the rat H4 receptor over the H3 subtype (pKi values are 5.75 and 7.46 for rat H3 and H4 receptors respectively). Also exhibits affinity for the human H4 receptor (pKi = 8.22).
Related Products: JNJ 7777120 Clobenpropit 4-MethylhistaminePotent KCa3.1 channel blocker
4864 | NS 6180
IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively. Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, norepinephrine and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM.
Related Products: Iberiotoxin GW 542573X TRAM 34Potent and selective LPA2 receptor antagonist
4878 | H2L5186303
IC50 values are 8.9, 1230 and 27354 nM for lysophosphatidic acid 2 (LPA2), LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay.
Related Products: GRI 977143 1-Oleoyl lysophosphatidic acid sodium salt H2L 5765834Potent and selective NaV1.8 channel blocker
4916 | PF 04885614
IC50 = 53 nM for human NaV1.8 channel. Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.
Related Products: A 887826 ProTx I A 803467

