Welcome to Tocris Bioscience
The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for April
IC50 = 397 nM. Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F mutation.Related Products: AG 490 Cucurbitacin I Cercosporamide
Rescues motorneurons undergoing apoptosis (EC50 = 20 nM). Blocks Aβ-induced cortical neuron apoptosis (EC50 ~51 nM). Does not inhibit ERK1 activity. Neuroprotective.Related Products: Anisomycin SP 600125 TCS JNK 6o
IC50 = 22 nM. Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice.Related Products: PP 1 PP 2 AZM 475271
Potent and selective polybromo 1 and SMARCA4 inhibitor (Kd values are 48 and 89 nM respectively). Also inhibits SMARCA2. Displays 30-fold selectivity over other sub-family branches. Accelerates FRAP recovery in cells at a concentration of 1 μM.Related Products: trans-Ned 19 MitoPY1 Methoxy-X04
pKd = 8.24. Exhibits no effect on acetylcholine, substance P or serotonin stimulated intestinal contraction.Related Products: Substance P Motilin (human, porcine) Serotonin
Find multiple products by catalog number
Tocris Bioscience currently has opportunities for an Analyst (Purification Specialist).
If you would like to be considered for any positions not currently advertised, we welcome your speculative application.
Win $1,000 Product Credit
April 26 - 30, 2014
San Diego CA, USA
Booth Number: 918