Welcome to Tocris Bioscience

Tocris provides the highest performing and most innovative range of research reagents available. Our range of over 3,000 products consists of small molecules, peptides and antibodies and is a unique collection of novel and exclusive tools for laboratory research.

Potent and selective PAR₂ agonist

3369 | AC 55541

pEC₅₀ = 6.7. Displays no activity at other PAR subtypes. Stimulates cell proliferation, PI hydrolysis and Ca²⁺ mobilization in vitro (pEC₅₀ values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.

Selective, non-competitive AMPA antagonist

2932 | CP 465022

IC₅₀ = 25 nM in rat cortical neurons. Displays potent anticonvulsant activity. Also significantly blocks the persistent component of Na_v1.6 channel activity. Brain penetrant and orally active.

Potent, broad spectrum MMP inhibitor

2961 | Batimastat

IC₅₀ values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively. Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo.

Potent and selective ATM kinase inhibitor

3544 | KU 55933

K_i = 2.2 nM, IC₅₀ values are 13, 2500, 9300, 16600, >100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-K, PI 4-K and ATR respectively. Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21^CIP1 levels in vitro.

Potent ErbB receptor family inhibitor

3352 | JNJ 28871063

IC₅₀ values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively. Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro.

Quick Order

Enter catalog numbers

New 2009-10 Catalog!

Tocris' new catalog is out now. Packed-full of cutting edge products, request a copy or view PDF today.

Tocris Events

Meet your representative

Tocris will be exhibiting at

Physiology 2009,

Dublin, Republic of Ireland

7 - 10th July, 2009

Booth No. 25