R&D Systems Inc. Tocris Bioscience Boston Biochem

Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,500 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for September

DNA methyltransferase inhibitor
5155 | SGI 1027

Inhibits the mammalian DNA methyltransferases DNMT3B, DNMT3A and DNMT1 (IC50 values are 7.5, 8 and 12.5 μM with Poly(dl-dC) as the substrate). Reactivates silenced tumor suppressor genes by reducing CpG island hypermethylation.

Related Products: Zebularine Decitabine RG 108
Potent C5a receptor peptide antagonist
5196 | PMX 205

IC50 = 31 nM. Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's Disease. Orally active and brain penetrant.

Related Products: NDT 9513727 Compstatin Compstatin control peptide
ATP-competitive inhibitor of IGF1R
5247 | NVP ADW 742

IC50 = 0.1-0.2 μM. Also inhibits c-Kit kinase activity (IC50 in the range of 3-5 μM). Exhibits a synergistic effect with imatinib, enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics etoposide (Cat. No. 1226) and carboplatin (Cat. No. 2626).

Related Products: Picropodophyllotoxin Insulin (human) recombinant
expressed in yeast
BMS 536924
Potent and selective FFA4 (GPR120) agonist
5257 | GSK 137647

pEC50 values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively. Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. Enhances glucose-stimulated insulin secretion in MIN6 cells. Induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614 (Cat. No. 5256).

Related Products: AH 7614 GW 9508 4-CMTB
Potent and selective smoothened (Smo) receptor antagonist
5262 | PF 5274857

Ki = 4.6 nM. Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant.

Related Products: Cyclopamine Purmorphamine SANT-1

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com/launch

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