R&D Systems Inc. Tocris Bioscience Boston Biochem

Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,500 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for December

TA1 receptor antagonist/inverse agonist
4518 | EPPTB

Exhibits a higher potency at the mouse trace amine 1 (TA1) receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively). Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).

Related Products: Octopamine Dopamine RuBi-Dopa
Selective BAZ2 bromodomain inhibitor
5266 | BAZ2-ICR

Kd values are 109 and 170 nM for BAZ2A and BAZ2B respectively. Exhibits 15-fold selectivity for the BAZ2 bromodomain over the CERC2 bromodomain and >100-fold selectivity over a range of other bromodomains. Accelerates FRAP recovery in a BAZ2A FRAP assay.

Related Products: (+)-JQ1 I-BET 151 OF 1
High affinity ghrelin receptor agonist
5272 | MK 0677

pKi = 8.14. Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC50 = 1.3 nM) and enhances GH plasma levels in vivo. Also attenuates isoproterenol-induced lipolysis in rat adipocytes in vitro. Orally bioavailable.

Related Products: Ghrelin (rat) YIL 781 [D-Lys3]-GHRP-6
Activator of BKCa (KCa1.1) channels
5276 | NS 19504

EC50 = 11 μM. Activates BK channels in native smooth muscle cells and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.

Related Products: Iberiotoxin NS 1619 NS 11021
Potent anaplastic lymphoma kinase inhibitor
5310 | ASP 3026

IC50 = 3.5 nM. Inhibits ALK tyrosine kinase activity in an ATP-competitive manner. Also inhibits ACK and ROS1 activity (IC50 values are 5.8 and 8.9 nM respectively). Decreases cell viability and proliferation, and induces apoptosis of NPM-ALK+ T-cell anaplastic large-cell lymphoma (ALCL) cells in vitro. Orally available.

Related Products: Crizotinib KRCA 0008 GSK 1838705

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com/launch

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Bio-Techne Events

One Day Symposium

Bio-Techne Symposium 2015

Autophagy in Inflammatory Diseases and Cancer

March 17, 2015

Paris, France