Welcome to Tocris Bioscience

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

HDAC 6 inhibitor

3402 | Tubacin

Inhibits the second deacetylase domain (DD2). Does not inhibit HDAC6 histone deacetylase activity; reversibly inhibits α-tubulin deacetylation. Increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.

AMPA receptor modulator

3911 | S 18986

Positive allosteric modulator of AMPA receptors. Exhibits cognitive enhancing properties in rodent behavioral models. Brain penetrant.

Orally active vasopressin V₁ antagonist

3924 | OPC 21268

Displays greater affinity for rat V₁ than human V₁ (K_i = 25 and 8800 nM respectively). Exhibits 1000-fold selectivity for V₁ receptors over V₂ receptors. Orally active.

Potent P2Y₆ agonist

4376 | 5-OMe-UDP trisodium salt

EC₅₀ = 0.08 μM. Displays greater potency at P2Y₆ than UDP (Cat.No. 3111) (EC₅₀ = 0.14 μM).

Allosteric Akt inhibitor

4398 | SC 66

Interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.

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