Welcome to Tocris Bioscience
The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
Featured Products
New for February
Selective D3 antagonist
4207 | SB 277011A
pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively. Brain penetrant.
Related Products: GSK 789472 U 99194 GR 103691Specific E3 ubiquitin ligase inhibitor
4375 | SMER 3
Specific inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of Rapamycin (Cat. No. 1292).
Related Products: PYR 41 IU1 LactacystinPotent and selective DAPK1 inhibitor
4301 | TC-DAPK 6
ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).
Related Products: DAPK Substrate Peptide Necrostatin-1 U0126mGlu5 antagonist
4394 | VU 0360223
Potent antagonist of mGlu5 (IC50 = 61 nM). Displays no activity at mGlu1-4 and mGlu7-8.
Related Products: MTEP Fenobam Bay 36-7620N-WASP inhibitor
4434 | Wiskostatin
Inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2-induced actin polymerization (EC50 ~ 4μM).
Related Products: 187-1, N-WASP inhibitor CK 666 Latrunculin AQuick Order
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