Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for February

Potent and selective GRK2/3 inhibitor
5642 | CMPD101

Potent and selective GRK2/3 inhibitor (IC50 values are 32 and 54 nM for GRK3 and GRK2, respectively). Exhibits selectivity for GRK2/3 over GRK1/5. Reduces DAMGO-induced desensitization and internalization of μ-opioid receptors.

Related Products: 8-Bromo-cGMP Gallein GRK2i
OX2 receptor antagonist; orally bioavailable
5645 | IPSU

OX2 receptor antagonist. Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. Decreases activity and increases sleep time in mice during the active phase, without affecting REM/NREM balance. Orally bioavailable. Brain penetrant.

Related Products: [Ala11,D-Leu15]-Orexin B TCS OX2 29 EMPA
Potent and selective HDAC2/3 inhibitor
5647 | MI 192

Potent and selective HDAC2/3 inhibitor (IC50 values are 16 and 30 nM, respectively). Exhibits >250-fold selectivity for HDAC2/3 over other HDAC isoforms. Promotes apoptosis of leukemia cell lines in vitro. Also attenuates IL-6 production in rheumatoid arthritis PBMCs in vitro.

Related Products: MC 1568 SAHA UF 010
Potent FXR antagonist
5656 | DY 268

Potent FXR antagonist (IC50 = 7.5 nM). Exhibits no detectable cytotoxicity in cell-based assays.

Related Products: GW 4064 GW 3965 Fexaramine
MAP4K4 (HGK) inhibitor
5752 | PF 06260933

MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.

Related Products: AEG 3482 (5Z)-7-Oxozeaenol FR 180204

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com

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Bio-Techne Events

TOX EXPO

The Society of Toxicology's 55th Annual Meeting and ToxExpo

March 14 - 16, 2016

New Orleans, LA, USA