Welcome to Tocris Bioscience

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Potent Abl kinase inhibitor

4730 | PPY A

Inhibits T315l mutant and wild-type Abl kinases (IC₅₀ values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.

Selective H₄ agonist

4769 | VUF 10460

Displays 50-fold selectivity for the rat H₄ receptor over the H₃ subtype (pK_i values are 5.75 and 7.46 for rat H₃ and H₄ receptors respectively). Also exhibits affinity for the human H₄ receptor (pK_i = 8.22).

Potent K_Ca3.1 channel blocker

4864 | NS 6180

IC₅₀ values are 9, 14 and 15 nM for rat, human and mouse erythrocyte K_Ca3.1 channels respectively. Exhibits ~ 50% inhibition of K_Ca1.1, K_V1.3, and K_V11.1 channels, norepinephrine and dopamine transporters, L-type Ca²⁺ channels and melatonin receptors at a concentration of 10 μM.

Potent and selective LPA₂ receptor antagonist

4878 | H2L5186303

IC₅₀ values are 8.9, 1230 and 27354 nM for lysophosphatidic acid 2 (LPA₂), LPA₃ and LPA₁ receptors respectively, in a LPA-elicited calcium mobilization assay.

Potent and selective Na_V1.8 channel blocker

4916 | PF 04885614

IC₅₀ = 53 nM for human Na_V1.8 channel. Exhibits selectivity for hNa_V1.8 over hNa_V1.6, hNa_V1.7, hNa_V1.1, hNa_V1.2 and hNa_V1.5 (IC₅₀ values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.

Quick Order

Find multiple products by catalog number

New Product E-alerts

Sign up for email updates from Tocris

20% Discount*

Potent, selective LRRK2 inhibitor

Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.

* Terms & conditions