R&D Systems Inc. Tocris Bioscience Boston Biochem

Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for April

JAK2 inhibitor
4580 | Atiprimod

IC50 = 397 nM. Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F mutation.

Related Products: AG 490 Cucurbitacin I Cercosporamide
Inhibitor of JNK signaling
4924 | CEP 1347

Rescues motorneurons undergoing apoptosis (EC50 = 20 nM). Blocks Aβ-induced cortical neuron apoptosis (EC50 ~51 nM). Does not inhibit ERK1 activity. Neuroprotective.

Related Products: Anisomycin SP 600125 TCS JNK 6o
Potent and selective Ack1 inhibitor
4946 | AIM 100

IC50 = 22 nM. Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice.

Related Products: PP 1 PP 2 AZM 475271
SMARCA4 and PB1 inhibitor
5072 | PFI 3

Potent and selective polybromo 1 and SMARCA4 inhibitor (Kd values are 48 and 89 nM respectively). Also inhibits SMARCA2. Displays 30-fold selectivity over other sub-family branches. Accelerates FRAP recovery in cells at a concentration of 1 μM.

Related Products: trans-Ned 19 MitoPY1 Methoxy-X04
Selective motilin receptor antagonist
5074 | ANQ 11125

pKd = 8.24. Exhibits no effect on acetylcholine, substance P or serotonin stimulated intestinal contraction.

Related Products: Substance P Motilin (human, porcine) Serotonin

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Tocris Events

Physiology 2014

Physiology 2014

June 30 - July 2, 2014

London, UK

Booth Number: 39