Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,500 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for August

Potent DYRK1B inhibitor
5232 | AZ 191

IC50 values are 17, 88 and 1890 nM for DYRK1B, DYRK1A and DYRK2 respectively. Inhibits DYRK1B-induced Gi phase cell cycle arrest in Panc-1 cells in vitro.

Related Products: INDY Harmine TC-S 7004
Selective TRPM3 agonist
5521 | CIM 0216

Exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. Stimulates insulin release from pancreatic islet cells in vitro. Evokes nocifensive behavior in mice.

Related Products: Ononetin Pregnenolone sulfate sodium salt RQ 00203078
Potent Smo antagonist
5554 | IHR 1

IC50 = 7.6 nM. Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.

Related Products: SAG Purmorphamine PF 5274857
High affinity, selective KCa2.2 blocker
5571 | Lei-Dab 7

Kd = 3.8 nM. Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive in vivo.

Related Products: TRAM 34 CyPPA NS 8593
Potent and selective PI 3-kinase p110α inhibitor
5595 | A66

IC50 = 32 nM. Exhibits >100-fold selectivity for p110α over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth in SK-OV-3 xenografts in mice.

Related Products: Wortmannin 740 Y-P ETP 45658

Quick Order

Find multiple products by catalog number

divider line

Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com

divider line

Bio-Techne Events

EMBO 2015

The 6th EMBO Meeting 2015

September 5 - 8, 2015

Birmingham, UK