Welcome to Tocris Bioscience
The leading supplier of high performance life science reagents
Tocris provides the highest performing and most innovative range of research reagents available. Our range of over 3,000 products consists of small molecules, peptides and antibodies and is a unique collection of novel and exclusive tools for laboratory research.
Featured Products
New for February
High affinity and selective GPR30 antagonist
3678 | G-15
Ki = 20 nM. Displays no affinity for ERα and ERβ at concentrations up to 10 μM. Inhibits agonist-induced calcium mobilization in vitro (EC50 of ~185 nM) and antagonizes the antidepressive effects of estrogen in vivo.
Related Products: G-1 ICI 182,780 TamoxifenSelective Pim kinase inhibitor
3714 | TCS PIM-1 4a
IC50 values are 24 and 100 nM for Pim-1 and Pim-2 respectively. Displays selectivity over a panel of ~50 other kinases tested. Exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro (IC50 = 17 μM).
Related Products: PIM-1 Inhibitor 2 TCS PIM-1 1Selective mTOR inhibitor
3725 | KU 0063794
IC50 ~10 nM for mTORC1 and mTORC2 respectively. Displays no activity at PI 3-K or 76 other kinases tested. Suppresses cell growth and induces G1 cell cycle arrest in vitro.
Related Products: Compound 401 PI 103 RapamycinPotent, collagenase-selective MMP inhibitor
2916 | Ro 32-3555
Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively. Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.
Related Products: Batimastat Marimastat UK 370106Primes ESCs for differentiation
3741 | Stauprimide
Interacts with NME2 and inhibits its nuclear translocation. Increases the efficiency of directed differentiation of mouse and human embryonic stem cells (ESCs) in vitro.
Buy Now / Print Quote
Find multiple products by catalog number
New 2009-10 Catalog!
Tocris' new catalog is out now. Packed-full of cutting edge products, request a copy or view PDF today.
Tocris Product News
Tocris Bioscience Awards Prize for Pharmacology Research
Chris Williams and Shaista Nisar, both PhD students at the University of Bristol, were selected as the best pharmacology research students of their year.