R&D Systems Inc. Tocris Bioscience Boston Biochem

Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,500 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for May

Potent human fatty acid synthase inhibitor
5303 | GSK 2194069

IC50 = 7.7 nM. Inhibits hFAS β-ketoacyl reductase activity. Also inhibits lipid synthesis and attenuates proliferation of A549 non-small-cell lung cancer cells (EC50 = 15 nM) in vitro.

Related Products: C 75 Orlistat SB 204990
IAP antagonist
5330 | AEG 40730

Binds to the BIR3 domain of cIAP1, cIAP2 and XIAP with nanomolar affinity. Reduces cIAP1, cIAP2 and XIAP protein levels in human breast cancer MDA-MB-231 cells. Induces apoptosis in combination with TNF, and potentiates TRAIL-mediated apoptosis in human colorectal carcinoma HCT 116 cells. Cell permeable.

Related Products: Embelin AZD 5582 UC 112
Potent TASK-3 channel blocker
5338 | PK-THPP

IC50 = 35 and 300 nM for TASK-3 and TASK-1 respectively. Increases breathing rate and induces respiratory alkalosis in rats.

Related Products: JNJ 303 MaxiPost ML 365
Potent and selective c-MET kinase inhibitor
5356 | SGX 523

IC50 = 4nM. Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.

Related Products: SU 5416 PF 04217903 XL 184
Potent and selective PLK1 inhibitor
5403 | TAK 960

IC50 values are 0.8, 16.9 and 50.2 nM for PLK1, PLK2 and PLK3 respectively. Exhibits >20-fold selectivity for PLK1 over FAK, MLCK and FES, and has minimal activity against a panel of 282 other kinases. Inhibits proliferation of a range of cancer cell lines in vitro and inhibits tumor growth of multiple human cancer cell xenografts in vivo. Orally bioavailable.

Related Products: Wortmannin GW 843682X SBE 13

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com

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Bio-Techne Events

FEBS 2015

40th FEBS Congress: The Biochemical Basis of Life

July 4 - 9, 2015

Berlin, Germany