Welcome to Tocris Bioscience

Tocris provides the highest performing and most innovative range of research reagents available. Our range of over 3,000 products consists of small molecules, peptides and antibodies and is a unique collection of novel and exclusive tools for laboratory research.

Axin stabilizer

3532 | endo-IWR 1

Inhibitor of Wnt signaling. Induces an increase in Axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

High affinity 5-HT_1A receptor antagonist

3282 | NAD 299

K_i = 0.6 nM in vitro. Enhances the action of selective 5-HT reuptake inhibitors and reverses citalopram-induced inhibition of serotonergic cell firing.

GSK-3β inhibitor

3835 | TWS 119

IC₅₀ = 30 nM. Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).

Selective Rho-kinase (ROCK) inhibitor

3846 | Y 39983

IC₅₀ values are 0.0036, 0.42 and 0.81 μM for ROCK, PKC and CaMKII respectively. Promotes neurite regeneration in vitro and induces axonal regeneration in vivo. Derived from Y-27632 (Cat. No. 1254).

TRPV1 antagonist

3875 | BCTC

Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC₅₀ values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.

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Tocris Product News

Agreement to Supply Pfizer Research Compounds

Tocris announces an agreement with Pfizer which will result in a wide range of Pfizer compounds being made available to the global research community.

New Product Guide

Highlights over 250 new products added in 2009/10. Request a copy or view PDF today.