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The leading supplier of high performance life science reagents
Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.
New for June
Inhibits T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.Related Products: Bosutinib AP 24534 GNF 2
Displays 50-fold selectivity for the rat H4 receptor over the H3 subtype (pKi values are 5.75 and 7.46 for rat H3 and H4 receptors respectively). Also exhibits affinity for the human H4 receptor (pKi = 8.22).Related Products: JNJ 7777120 Clobenpropit 4-Methylhistamine
IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively. Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, norepinephrine and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM.Related Products: Iberiotoxin GW 542573X TRAM 34
IC50 values are 8.9, 1230 and 27354 nM for lysophosphatidic acid 2 (LPA2), LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay.Related Products: GRI 977143 1-Oleoyl lysophosphatidic acid sodium salt H2L 5765834
IC50 = 53 nM for human NaV1.8 channel. Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.Related Products: A 887826 ProTx I A 803467
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Potent, selective LRRK2 inhibitor
Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.