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The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuardorian Poison Frog

Tocris provides the highest performing and most innovative range of research reagents available. Our range of over 3,000 products consists of small molecules, peptides and antibodies and is a unique collection of novel and exclusive tools for laboratory research.

Featured Products

New for September

Dynamin inhibitor
3982 | Mdivi 1

IC50 = 1 - 10 μM. Attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis.

Related Products: CP 96345 Dynamin inhibitory peptide NSC 23766
Hsp70 inhibitor
3803 | VER 155008

IC50 = 0.5 μM. Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78; selective against Hsp90β.

Related Products: Pifithrin-μ Macbecin I 17-AAG
Positive allosteric modulator of mGlu2
3949 | CBiPES

IC50 = 98.2 nM. Mimics the action of LY 379268 (Cat. No. 2453); attenuates ketamine-evoked histamine release in vivo.

Related Products: LY 379268 LY 354740 LY 341495
Potent γ-secretase inhibitor
2870 | BMS 299897

IC50 = 12 nM. Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.

Related Products: Compound W DAPT JLK 6
α5-selective GABAA inverse agonist
3817 | MRK 016

EC50 = 3 nM. Exhibits affinity at benzodiazepine binding site of recombinant human GABAA receptors (Ki values are 0.77 nM, 0.83 nM, 0.85 nM and 1.4 nM for α3-, α1-, α2-, and α5-containing respectively). Increases long-term potentiation (LTP) in mouse hippocampal slices. Exhibits no anxiogenic or proconvulsant activity.

Related Products: TB 21007 (+)-Bicuculline TCS 1205

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Tocris Product News

Tocris partners with Jena Bioscience

Jena Bioscience

Jena Bioscience products are now available from Tocris USA. View the Jena range here.

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New Product Guide

New Product Guide Spring 2010

Highlights over 250 new products added in 2009/10. Request a copy or view PDF today.

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