R&D Systems Inc. Tocris Bioscience Boston Biochem

Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 3,500 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for October

High affinity and selective EP4 antagonist
3565 | ONO AE3 208

Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively. Displays no affinity for EP1, EP2, DP or IP receptors (Ki >10 μM). Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis. Orally active.

Related Products: L-161,982 TCS 2510 GW 627368
Potent and selective G9a/GLP histone lysine methyltransferase inhibitor
5163 | A 366

IC50 = 3.3 nM. Exhibits >1000 selectivity for G9a/GLP over 21 other methyltransferases. Decreases levels of lysine 9 dimethylation on histone H3 (H3K9Me2) in PC3 cells.

Related Products: 3-Deazaneplanocin A TC-E 5003 UNC 0642
Potent and selective lactate dehydrogenase A inhibitor
5189 | GSK 2837808A

IC50 values are 1.9 and 14 nM for LDHA and LDHB respectively. Inhibits lactate production in multiple cancer cell lines. Reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells. Inhibits proliferation and induces apoptosis in Snu398 cells. Cell permeable.

Related Products: Galloflavin CHC SZL P1-41
Potent and selective FABP4 inhibitor
5258 | BMS 309403

Ki values are <2, 250 and 350 nM for FABP4, FABP3 and FABP5 respectively. Decreases fatty acid uptake in adipocytes in vitro and reduces atherosclerotic lesion area in a mouse model of atherosclerosis. Reduces blood glucose levels and increases insulin sensitivity in a mouse model of obesity. Orally active.

Related Products: AS 2034178 AH 7614 GSK 137647
Potent MTH1 inhibitor
5280 | SCH 51344

Kd = 49 nM. Inhibits Ras-induced malignant transformation and increases α-actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.

Related Products: Fumonisin B1 EHT 1864 Salirasib

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com/launch

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Bio-Techne Events

2014 ASCB/IFCB meeting

ASCB/IFCB 2014

December 6 - 10, 2014

Philadelphia, USA

Booth Number: 515