Welcome to Tocris Bioscience

The leading supplier of high performance life science reagents

Ameerega bilingua: Ecuadorian Poison Frog

Tocris is the leading supplier of novel and exclusive tools for laboratory research. Our unique collection of over 4,000 life science reagents consists of GPCR ligands, neurotransmitters, ion channel modulators and signaling inhibitors.

Featured Products

New for December

Enhances HDR efficiency
5342 | SCR7 pyrazine

Enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro. Inhibits nonhomologous end-joining (NHEJ).

Related Products: L-755,507 Azidothymidine KU 0060648
High affinity C5a receptor antagonist
5455 | W 54011

Ki = 2.2 nM. Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).

Related Products: Compstatin PMX 205 PMX 53
Stat3 inhibitor; blocks cancer stem cell self-renewal
5522 | Napabucasin

Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.

Related Products: Cyclopamine Stattic BRD 7116
Potent hM3Dq DREADD receptor agonist
5548 | DREADD agonist 21

EC50 = 1.7 nM. Highly selective for hM3Dq DREADD receptors over endogenous hM3 receptors.

Related Products: J 104129 Clozapine N-oxide Salvinorin B
Potent and selective LIMK inhibitor; antitumor
5626 | SR 7826

IC50 values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively. Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.

Related Products: Y-27632 LIMKi 3 T 5601640

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Introducing Bio-Techne

Tocris - a Bio-techne brand

We are pleased to introduce you to Bio-Techne, the new trade name for Tocris' parent company. For more information, please visit bio-techne.com

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Bio-Techne Events

Bio-Techne Symposium 2016

Stem Cells and Organoids as Models of Tissue Differentiation and Disease

January 12, 2016

London, UK