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TRPV Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| TRPV1 | Human | TRPV1 | NM_018727 | Q8NER1 |
| Mouse | Trpv1 | NM_001001445 | Q704Y3 | |
| Rat | Trpv1 | NM_031982 | O35433 | |
| TRPV2 | Human | TRPV2 | NM_016113 | Q9Y5S1 |
| Mouse | Trpv2 | NM_011706 | Q9WTR1 | |
| Rat | Trpv2 | NM_017207 | Q9WUD2 | |
| TRPV3 | Human | TRPV3 | NM_145068 | Q8NET8 |
| Mouse | Trvp3 | NM_145099 | Q8K424 | |
| Rat | Trpv3 | NM_001025757 | Q4QYD9 | |
| TRPV4 | Human | TRPV4 | NM_021625 | Q96Q92 |
| Mouse | Trpv4 | NM_022017 | Q9EPK8 | |
| Rat | Trpv4 | NM_023970 | Q9ERZ8 | |
| TRPV5 | Human | TRPV5 | NM_019841 | Q9NQA5 |
| Mouse | Trpv5 | NM_001007572 | P69744 | |
| Rat | Trpv5 | NM_053787 | Q9JIP0 | |
| TRPV6 | Human | TRPV6 | NM_014274 | Q9H1D0 |
| Mouse | Trpv6 | NM_022413 | Q91WD2 | |
| Rat | Trpv6 | NM_053686 | Q9R186 |
TRPV Pharmacological Data
|
Receptor (other names) |
TRPV1 VR1, OTRPC1, Vanilloid/capsaicin receptor |
TRPV2 VRL-1, OTRPC2, GRC |
TRPV3 VRL-3 |
TRPV4 VRL-2, OTRPC4, VR-OAC, TRP12 |
TRPV5 OTRPC3, ECaC, ECaC1, CaT2 |
TRPV6 ECaC2, CaT1, CaT-L |
|---|
| Description | Vanilloid receptor, noxious thermosensor, non-selective cation channel | Noxious heat, noxious thermosensor, non-selective cation channel | Warmth sensor, moderately selective Ca2+ channel | Osmosensor, moderately selective Ca2+ channel | Highly selective Ca2+ channel | Highly selective Ca2+ channel |
| Receptor distribution | Dorsal root and trigeminal ganglia, brain, spinal cord, pancreas, skin epithelial, bladder | Dorsal root and trigeminal ganglia, brain, spinal cord, spleen, lung, mast cells, vascular smooth muscle | Brain (cortex, thalamus), skin, hair follicles, tongue, stomach, spinal cord, superior clavicular, dorsal root and trigeminal ganglia | Brain, liver, kidney, adipose tissue, heart, testis, salivary gland, trachea | Intestine, kidney, placenta, brain | Kidney, intestine |
| Tissue Function | Pain sensation, vasodilation | Thermal pain sensation, mast cell function | Putative warm sensation | Osmolarity sensing with thermal modulation | Active Ca+ (re)absorption | Active Ca2+ (re)absorption |
| Key Activators |
Capsaicin (0462) Resiniferatoxin (1137) Anandamide (1339) Olvanil (0934) Heat (threshold ~ 43oC) Protons Ethanol |
Noxious heat (threshold =52oC) IGF-1 |
Increasing temperature (~35oC) | Reduced osmolarity | None (constitutively active) | None (constitutively active) |
| Antagonists |
Capsazepine (0464) 5'-Iodoresiniferatoxin (1362) Ruthenium red (1439) JNJ 17203212 (3361) AMG 9810 (2316) PIP2 |
Ruthenium red (1439) SKF 963365 (1147) La3+ |
Ruthenium red (1439) | Ruthenium red (1439) |
Ruthenium red (1439) La3+ |
Ruthenium red (1439) La3+ |
References
Gunthorpe et al (2002) The diversity in the vanilloid (TRPV) receptor family of ion channels. TiPS 23 183. Clapham et al (2003) International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels; transient receptor potential channels. Pharmacol.Rev. 55 591. Alexander et al (2004) Guide to receptors and channels. Br.J.Pharmacol. 141 S89.