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Prostanoid Receptor Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| EP1 | Human | PTGER1 | NM_000955 | P34995 |
| Mouse | Ptger1 | NM_013641 | P35375 | |
| Rat | Ptger1 | NM_013100 | P70597 | |
| EP2 | Human | PTGER2 | NM_000956 | P43116 |
| Mouse | Pyry2 | NM_008964 | Q62053 | |
| Rat | Ptger2 | NM_031088 | Q62928 | |
| EP4 | Human | PTGER3 | NM_000957 | P43115 |
| Mouse | Ptger3 | NM_011196 | P30557 | |
| Rat | Ptger3 | NM_012704 | P34980 | |
| EP4 | Human | PTGER4 | NM_000958 | P35408 |
| Mouse | Ptger4 | NM_008965 | P32240 | |
| Rat | Ptger4 | NM_032076 | P43114 | |
| TP | Human | TBXA2R | NM_201636 | P21731 |
| Mouse | Tbxa2r | NM_009325 | P30987 | |
| Rat | Tbxa2r | NM_017054 | P34978 | |
| FP | Human | PTGFR | NM_000959 | P43088 |
| Mouse | Ptgfr | NM_008966 | P43117 | |
| Rat | Ptgfr | NM_013115 | P43118 | |
| IP | Human | PTGIR | NM_000960 | P43119 |
| Mouse | Ptgir | NM_008967 | P43252 | |
| Rat | Ptgir | NM_001077644 | P43253 | |
| DP | Human | PTGDR | NM_000953 | Q13258 |
| Mouse | Ptgdr | NM_008962 | P70263 | |
| Rat | Ptgdr | NM_022241 | O35932 |
Pathway of Prostanoid Production
Prostanoid Receptor Pharmacological Data
| Receptor Subtype | EP1 | EP2 | EP3 | EP4 |
|---|
| Transduction Mechanism | Gq → ↑ PI hydrolysis/Ca2+ | Gs → ↑ cAMP | Various (splice variants), mainly ↓ cAMP | Gs → ↑ cAMP |
| Agonist Potencies | PGE2 > PGF2, PGI2 > PGD2, TXA2 | PGE2 > PGF2, PGI2 > PGD2, TXA2 | PGE2 > PGF2, PGI2 > PGD2, TXA2 | PGE2 > PGF2, PGI2 > PGD2, TXA2 |
| Receptor Distribution | Kidney, lung (mouse) | Lung, placenta (human), uterus, lung, ileum, liver, thymus, spleen (mouse) | Kidney, uterus, stomach, brain, thymus, lung, spleen (mouse), kidney, pancreas, uterus, heart, liver, testis, ovary (human) | Ileum, thymus, spleen, lung, heart, stomach, uterus (mouse) |
| Tissue Functions | GI contraction, tracheal contraction (guinea-pig), gastric fundus contraction | Bronchodilatation (guinea-pig, cat), myometrial inhibition (human,baboon), vasodepression (cat, guinea-pig) | Inhibition of gastric acid secretion (human, dog, rat), myometrial stimulation (human, cat,rat, hamster) | Vasodilatation (dog), bronchodilatation (rat) |
| Receptor Subtype | DP | FP | IP | TP |
|---|
| Transduction Mechanism | Gs → ↑ cAMP | Gq → ↑ PI hydrolysis/Ca2+ |
Gs → ↑ cAMP ↑ PI hydrolysis/Ca2+ |
Gq → ↑ PI hydrolysis/Ca2+ |
| Agonist Potencies | PGD2 >> PGE2 > PGF2 > PGI2, TXA2 | PGF2 > PGD2 > PGE2 > PGI2, TXA2 | PGI2 >> PGD2 ,PGE2, PGF2 > TXA2 | TXA2 = PGH2 >> PGD2, PGE2, PGF2, PGI2 |
| Receptor Distribution | Ileum, lung, stomach, uterus (mouse) | Corpus luteum, kidney, lung, heart, stomach (mouse), overy, small intestine, prostate, spleen, testis (human) | Aorta, lung, heart, kidney (human), thymus, spleen (mouse), NTS, dorsal horn (rat) | Thymus, spleen, lung, kidney, heart, uterus (mouse) |
| Tissue Functions | Inhibition of platelet aggregation | Luteolysis | Vasodepression, inhibition of platelet aggregation | Vaso- and bronchoconstriction, platelet aggregation, myometrial stimulation |
References
IUPHAR Compendium of receptor characterization and classification. (2000) 2nd Edition. IUPHAR Media. Breyer et al (2001) Prostanoid receptors: subtypes and signaling. Ann.Rev.Pharmacol.Toxicol. 41 661.