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Nicotinic Receptor (nAChRs) Pharmacological Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| α1 (muscle) | Human | CHRNA1 | NM_000079 | P02708 |
| Mouse | Chrna1 | NM_007389 | P04756 | |
| Rat | Chrna1 | NM_024485 | P25108 | |
| α2 (neuronal) | Human | CHRNA2 | NM_000742 | Q15822 |
| Mouse | Chrna2 | NM_144803 | Q91X60 | |
| Rat | Chrna2 | NM_133420 | P12389 | |
| α3 | Human | CHRNA3 | NM_000743 | P32297 |
| Mouse | Chrna3 | NM_145129 | Q8R4G9 | |
| Rat | Chrna3 | NM_052805 | P04757 | |
| α4 | Human | CHRNA4 | NM_000744 | P43681 |
| Mouse | Chrna4 | NM_015730 | O70174 | |
| Rat | Chrna4 | NM_024354 | P09483 | |
| α5 | Human | CHRNA5 | NM_000745 | P30532 |
| Mouse | Chrna5 | NM_176844 | Q2MKA5 | |
| Rat | Chrna5 | NM_017078 | P20420 | |
| α6 | Human | CHRNA6 | NM_004198 | Q15825 |
| Mouse | Chrna6 | NM_021369 | Q9R0W9 | |
| Rat | Chrna6 | NM_057184 | P43143 | |
| α7 | Human | CHRNA7 | NM_000746 | P36544 |
| Mouse | Chrna7 | NM_007390 | P49582 | |
| Rat | Chrna7 | NM_012832 | Q05941 | |
| α9 | Human | CHRNA9 | NM_017581 | Q9UGM1 |
| Mouse | Chrna9 | NM_001081104 | NP_001074573 | |
| Rat | Chrna9 | NM_022930 | P43144 | |
| α10 | Human | CHRNA10 | NM_020402 | Q9GZZ6 |
| Mouse | Chrna10 | NM_001081424 | NP_001074893 | |
| Rat | Chrna10 | NM_022639 | Q9JLB5 | |
| β1 | Human | CHRNB1 | NM_000747 | P11230 |
| Mouse | Chrnb1 | NM_009601 | P09690 | |
| Rat | Chrnb1 | NM_012528 | P25109 | |
| β2 | Human | CHRNB2 | NM_000748 | P17787 |
| Mouse | Chrnb2 | NM_009602 | Q9ERK7 | |
| Rat | Chrnb2 | NM_019297 | P12390 | |
| β3 | Human | CHRNB3 | NM_000749 | Q05901 |
| Mouse | Chrnb3 | NM_173212 | Q8BMN3 | |
| Rat | Chrnb3 | NM_133597 | P12391 | |
| β4 | Human | CHRNB4 | NM_000750 | P30926 |
| Mouse | Chrnb4 | NM_148944 | Q8R493 | |
| Rat | Chrnb4 | NM_052806 | P12392 | |
| δ | Human | CHRND | NM_000751 | Q07001 |
| Mouse | Chrnd | NM_021600 | P02716 | |
| Rat | Chrnd | NM_019298 | P25110 | |
| ε | Human | CHRNE | NM_000080 | Q04844 |
| Mouse | Chrne | NM_009603 | P20782 | |
| Rat | Chrne | NM_017194 | P09660 | |
| γ | Human | CHRNG | NM_005199 | P07510 |
| Mouse | Chrng | NM_009604 | P04760 | |
| Rat | Chrng | NM_019145 | P18916 |
Nicotinic Pharmacological Receptor Data
| nACh Receptor Subtype | α2β4 | α7 | α3β4 | |
| Localisation | CNS - Cortex, thalamus, hippocampus,striatum | Autonomic ganglia, hippocampus, limbic system, cortex, chick retina | Autonomic ganglia, adrenal gland, hippocampus | |
| Tissue Function | Synaptic transmission, anti-nociception, anxiolytic, memory | Synaptic transmission, auditory gating, memory | Synaptic transmission | |
| Key Compounds | Ki (nM) | |||
| Agonists |
(±-)Anatoxin A (0789) (-)-Cytisine (1390) (±)-Epibatidine (0684) (-)-Lobeline (1077) RJR 2403 (1053) UB 165 (1348) |
1.3-4.2 0.14-2.7 0.01-0.05 4-50 26 0.27-0.44 |
707-1840 1400-3883 20.6-233 11000-13100 36000 2790 |
ND 56-195 0.38 480 ND ND |
| Antagonists |
Chlorisinamide (1001) Dihydro-β-erythroidine (2349) Methylcaconitine (1029) TMPH (2438) |
686000 370* 3700-6100 1400* |
ND ND 0.69-10.3 1000* |
ND 23100* ND 200* |
*IC50 values