Pharmacology
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7-TM Receptors
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Cellular Processes
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All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
Caged Compounds
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Screening Libraries
Ligand Sets
Other Product Types
Research Area
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
Properties of Imidazoline Receptors
| Receptor | I1 | I2 | I3 |
|---|
| Location | Lateral reticular nucleus, locus ceruleus, kidney, platelets, pancreas | Interpeduncular and arcuate nuclei, pineal gland, liver, kidney, heart, striated muscle, MAO | Pancreatic β cells |
| Transduction Mechanism | ↑ Diacylglycerol and arachidonic acid | Unknown | Unknown |
| Key Selective Ligands |
AGN 192403 (1072) Clonidine (0690) Rilmenidine (0790) |
BU 239 (0726) RS 45041-190 (0889) 2-BFI (0348) |
KU14R (1131) |
| Putative Endogenous Ligands | Agmatine (0842), Harmane (1132) | ||