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All Products
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Small Molecules
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GABA Transporter Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|
| GAT-1 | Human | SLC6A1 | NM_003042 | P30531 |
| Mouse | Slc6a1 | NM_178703 | P31648 | |
| Rat | Slc6a1 | NM_024371 | P23978 | |
| GAT-2 | Human | SLC6A13 | NM_016615 | Q9NSD5 |
| Mouse | Slc6a12 | NM_133661 | P31651 | |
| Rat | Slc6a13 | NM_133623 | P31646 | |
| GAT-3 | Human | SLC6A11 | NM_014229 | P48066 |
| Mouse | Slc6a13 | NM_144512 | P31649 | |
| Rat | Slc6a11 | NM_024372 | P31647 | |
| BGT-1 | Human | SLC6A12 | NM_003044 | P48065 |
| Rat | Slc6a12 | NM_017335 | P48056 | |
| VGAT | Human | SLC32A1 | NM_080552 | Q9H598 |
| Mouse | Slc32a1 | NM_009508 | O35633 | |
| Rat | Slc32a1 | NM_031782 | O35458 |
Properties of GABA Transporters
| Transporter | GAT-1 | GAT-2 | GAT-3 | BGT-1 |
|---|
| Tissue Localization1 | Mainly neuronal cells in CNS | Epithelial, glial and neuronal cells (mainly CNS) | Mainly glial cells in CNS and retina | Probably mainly glial cells in CNS and kidney |
| Selected Inhibitors | IC50 (μM) | |||
| β-Alanine (0206) | 56902 | 192 | 582 | 13202 |
| CI 966 (1296) | 0.262 | 2972 | 3332 | 3002 |
| Guvacine (0234) | 142 | 582 | 1192 | 18702 |
| (±)-Nipecotic acid (0236) | 82 | 382 | 1062 | 23702 |
| NNC 711 (1779) | 0.042 | 1712 | 17002 | 6222 |
| SKF 89976A (1081) | 0.132 | 5502 | 9442 | 72102 |
| (S)-SNAP 5114 (1561) | 3883 | 213 | 53 | 1403 |
IC50 values are for inhibition of [3H]-GABA uptake by cloned human GAT-1, rat GAT-2, human GAT-3 and human BGT-1.
References
- Gadea and Lopez-Colome (2001) Glial transporters for glutamate, glycine and GABA: II GABA transporters. J.Neurosci.Res. 63 461.
- Borden et al (1994) Tiagabine, SK&F 89976-A, Ci 966 and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219.
- Bordern et al (1994) Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels 2 207.