Pharmacology
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Cellular Processes
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Stem Cells
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Product Type
All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
Caged Compounds
Fluorescent Probes
Screening Libraries
Ligand Sets
Other Product Types
Research Area
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
Properties of Adenylyl Cyclases
| Subtype | Endogenous Activators | Endogenous Inhibitors |
|---|
| AC1 |
Ca2+/Calmodulin PKC-evoked phosphorylation |
Gαi |
| AC2 |
Gβγ PKC-evoked phosphorylation |
- |
| AC3 |
Ca2+/Calmodulin PKC-evoked phosphorylation |
Gαi CaMKII-evoked phosphorylation |
| AC4 | Gβγ | PKC-evoked phosphorylation |
| AC5 | PKC-evoked phosphorylation |
Gαi Ca2+ PKA-evoked phosphorylation |
| AC6 | - |
Gαi Ca2+ PKA-evoked phosphorylation PKC-evoked phosphorylation |
| AC7 | PKC-evoked phosphorylation | - |
| AC8 | Ca2+ | - |
| AC9 | - | Ca2+/calcineurin |
References
Alexander et al (2008) Guide to receptors and channels (GRAC) 3rd edn. Br.J.Pharmacol. 153 S176.