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All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
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Screening Libraries
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Research Area
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CRF Receptor Data
| Receptor Subtype | CRF1 | CRF2a | CRF2b |
|---|
| Transduction Mechanism | Activates Gs | Activates Gs | Activates Gs |
| Key Compounds | Ki (nM) |
|---|
| Agonists |
CRF (human, rat) (1151) Urocortin (rat) (1605) Sauvagine (1609) Stressin I (1608) |
11 13 9.4 1.5 |
44 1.5 9.9 224 |
38 0.97 3.8 224 |
| Antagonists |
Astressin (1606) α-helical CRF 9-41 (1184) NBI 27914 (1591) CP 154526 (2779) CP 376395 (3212) K 41498 (2070) |
2 17 2 2.7 12 425 |
1.5 5 > 10000 > 10000 > 10000 0.66 |
1 0.97 - > 10000 > 10000 0.62 |
References
Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312. Maciejewski-Lenoir et al (200) Selective impairment of corticotropin-releasing factor1 (CRF1) receptor-mediated function using CRF coupled to saporin. Endocrinology 141 498.