Pharmacology
All Targets
7-TM Receptors
Ion Channels
Nuclear Receptors
Enzyme-Linked Receptors
Transporters
Enzymes
Other Pharmacology
Cellular Processes
Angiogenesis
Apoptosis
Cell Cycle
Cell Metabolism
Cytoskeleton & Motor Proteins
ECM & Adhesion Molecules
Signal Transduction
Stem Cells
Signaling Pathways 
Product Type
All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
Caged Compounds
Fluorescent Probes
Screening Libraries
Ligand Sets
Other Product Types
Research Area
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
Product Type
All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
Caged Compounds
Fluorescent Probes
Screening Libraries
Ligand Sets
Other Product Types
Research Area
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
Angiotensin Receptor Data
| Receptor Subtype | AT1 Receptors | AT2 Receptors | AT4 Receptors |
|---|
| Transduction Mechanism | Gq/11 | Gi/o | Unknown |
| Primary Locations | Liver, kidney, adrenal gland, lung | Brain, adrenal medulla, heart, uterus | Kidney, brain, adrenal gland, heart, liver, lung |
| Tissue Functions | Mediates vasoconstriction, regulates aldosterone and vasopressin release, salt and water retention, cell proliferation and migration, sympathetic stimulation | Counterbalances effects of the AT1 receptor | Regulates blood flow and renal tubular reabsorption, affects cardiac hypertrophy and memory acquisition |
| Selective Agonists | - | CGP 42112 (2569) | - |
| Selective Antagonists |
ZD 7155 (1211) EMD 66684 (1849) |
PD 123319 (1361) | - |
References
Gasparo et al (2000) International Union of Pharmacology XXIII. The angiotensin II receptors. Pharmacol.Rev. 52 415. Alexander et al (2000) Guide to receptors and channels. Br.J.Pharmacol. 141 Suppl.1.