Apoptosis

Apoptosis is defined as a mechanism of cell death which occurs after sufficient cellular damage. It occurs normally during development and aging and is considered a vital component of cell turnover, cell development and function of the immune system. It occurs as a defense mechanism such as in immune reactions or when cells are damaged by disease or noxious agents.

Apoptosis Product Areas

14.3.3 Proteins Apoptosis Inducers Bcl-2 Family Caspases

Inhibitor of Apoptosis p53 Other Apoptosis

Apoptosis and Disease

Apoptosis, in general, confers advantages during an organism's life cycle. Between 50 billion and 70 billion cells die each day due to apoptosis in the average human adult. In a year, this amounts to the proliferation and subsequent destruction of a mass of cells equal to an individual's body weight. Inappropriate apoptosis is a factor in many human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. The ability to modulate the life or death of a cell is recognized for its profound therapeutic potential, and research continues to focus on the elucidation of the cell cycle machinery and signaling pathways that control cell cycle arrest and apoptosis.

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Cancer Research Guide

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Highlights over 350 products for cancer research. Request a copy or view PDF today.

The p53 Tumor Suppressor Response

Written by Christopher J. Brown et al

A summary of the main strategies that may be utilized to reactivate p53 including several small molecules and peptides which act to stabilize p53 and rescue wild-type activity.

Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

A summary of the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation. Request a copy or view PDF today.