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Cancer Research
Cancer is a term used to define a group of diseases in which abnormal cells divide without control, are able to invade neighboring tissues/organs and metastasize. Cancer has been characterized by six hallmarks; self sufficiency in proliferative growth signals, insensitivity to growth inhibitors, evasion of apoptosis, limitless replicative potential, ability to develop blood vessels (angiogenesis), and tissue invasion and metastasis.
Cancer Product Areas
Cancer Types
There are more than 100 different types of human cancer - most named after the organ or type of cell in which they start. Cancer types can be grouped into broad categories, the five main ones being:
- Carcinoma - cancer that begins in the skin or in tissues that line internal organs.
- Sarcoma - cancer that begins in connective or supportive tissue (bone, cartilage, muscle).
- Leukemia - cancer that starts in blood-forming tissue such as the bone marrow. Abnormal blood cells are produced which enter the bloodstream.
- Lymphoma and myeloma - cancers that begin in the immune system.
- CNS cancers - cancers that begin in the tissues of the brain and spinal cord.
Therapeutics
Due to the prevalence of cancer within the population, investigation of potential therapeutic targets is the focus of intense research. Current therapeutic research is focusing on identifying new cellular targets for intervention, developing drugs based on small molecules, antibodies or nucleic acids. New drugs specifically targeting intracellular kinases, growth factor receptors or the proteasome are beginning to be used as frontline therapies, often in combination with established chemotherapeutic agents.
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Cancer Research Guide
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Highlights over 350 products for cancer research. Request a copy or view PDF today.
MAPK Signaling Review
Written by Elma Zaganjor and Melanie H. Cobb, leading experts. Request a copy or view PDF today.
Autophagy Review
Written by Patricia Boya and Patrice Codogno, leading experts in the field. Request a copy or view PDF today.
Programmed Cell Death
Written by Bram van Raam and Guy Salvesen
A summary of the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation. Request a copy or view PDF today.
The p53 Tumor Suppressor Response
Written by Christopher J. Brown et al
A summary of the main strategies that may be utilized to reactivate p53 including several small molecules and peptides which act to stabilize p53 and rescue wild-type activity.
Akt Pathway
Akt signaling is involved in fundamental cellular processes such as protein synthesis, metabolism, proliferation and survival. View pathway or download PDF today.
Apoptosis Pathway
Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.
MAPK Pathway
The MAPK family kinases respond to extracellular stimuli such as heat and stress to mediate intracellular signals. View pathway or download PDF today.
mTOR Pathway
The mTOR complexes (mTORC1 and 2) respond to intra- and extracellular signals to mediate cell growth, proliferation and survival. View pathway or download PDF today.
p53 Pathway
Signals through the p53 pathway are integral in the control of the cellular response different types of stress. View pathway or download PDF today.
VEGF Pathway
VEGF signaling regulates vascular development (vasculogenesis) and the formation of new blood vessels (angiogenesis). View pathway or download PDF today.
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5th Conference on Advances in Molecular Mechanisms Underlying Neurological Disorders
June 23 - 26, 2013
Bath, UK