R&D Systems Inc. Tocris Bioscience Boston Biochem

Cancer Research

Cancer is a term used to define a group of diseases in which abnormal cells divide without control, are able to invade neighboring tissues/organs and metastasize. Cancer has been characterized by six hallmarks; self sufficiency in proliferative growth signals, insensitivity to growth inhibitors, evasion of apoptosis, limitless replicative potential, ability to develop blood vessels (angiogenesis), and tissue invasion and metastasis.

Cancer Product Areas

Cancer Types

There are more than 100 different types of human cancer - most named after the organ or type of cell in which they start. Cancer types can be grouped into broad categories, the five main ones being:

  • Carcinoma - cancer that begins in the skin or in tissues that line internal organs.
  • Sarcoma - cancer that begins in connective or supportive tissue (bone, cartilage, muscle).
  • Leukemia - cancer that starts in blood-forming tissue such as the bone marrow. Abnormal blood cells are produced which enter the bloodstream.
  • Lymphoma and myeloma - cancers that begin in the immune system.
  • CNS cancers - cancers that begin in the tissues of the brain and spinal cord.
Therapeutics

Due to the prevalence of cancer within the population, investigation of potential therapeutic targets is the focus of intense research. Current therapeutic research is focusing on identifying new cellular targets for intervention, developing drugs based on small molecules, antibodies or nucleic acids. New drugs specifically targeting intracellular kinases, growth factor receptors or the proteasome are beginning to be used as frontline therapies, often in combination with established chemotherapeutic agents.

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Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

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Autophagy Review

Autophagy Review

Written by Patricia Boya and Patrice Codogno, leading experts in the field. Request a copy or view PDF today.

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MAPK Signaling Review

MAPK Signaling Review

Written by Elma Zaganjor and Melanie H. Cobb, leading experts. Request a copy or view PDF today.

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Autophagy: Mechanisms and Function

Written by Patricia Boya and Patrice Codogno

Autophagy Poster

'Autophagy: Mechanisms and Function' summarizes the molecular machinery, physiology and pathology of autophagy. Request a copy or view PDF today.

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Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Poster

A summary of the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation. Request a copy or view PDF today.

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The p53 Tumor Suppressor Response

Written by Christopher J. Brown et al

p53 Poster

A summary of the main strategies that may be utilized to reactivate p53 including several small molecules and peptides which act to stabilize p53 and rescue wild-type activity.

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New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

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