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Category: EnzymesarrowKinasesarrowMAPK/MAPKK
Cat.No. Product Name
1264 SB 202190
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SB 202190

Other Information:

Sold with the permission of GlaxoSmithKline
Chemical Name: 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] phenol

Biological Activity:

A highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively).

Technical Data:

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M.Wt: 331.35
Formula: C20H14N3OF
Storage: Desiccate at -20°C
Solubility: Soluble to 100 mM in DMSO
Purity: >99%
CAS No: [152121-30-7]

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    References:

    Jiang et al (1996) Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). J.Biol.Chem. 271 17920. Frantz et al (1998) The activation of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding. Biochemistry 37 13846. Nemoto et al (1998) Induction of apoptosis by SB 202190 through inhibition of p38β mitogen-activated protein kinase. J.Biol.Chem. 273 16415. Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95.
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    Keywords: SB 202190, Kinases, Potent, Selective Inhibitor Of P38 MAPK, SB202190, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Function & Modulation of MAP Kinase Pathways
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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