Recognises rat KA2 and migrates at a band of ~ 120
kDa. Also predicted to cross-react with mouse and human homologues.
Immunogen:
KLH conjugated synthetic peptide
([C]-TSPPRPRPGPTGPRELTEHE) corresponding to C-terminal amino acids 960-979 of
rat precursor KA2 receptor (Accession No. Q63273) with a cysteine added at the
N-terminus of the peptide. 50 μg
of immunogen is provided with the antibody as a blocking peptide and can also
be purchased separately (Cat. No. 2127).
Applications:
IB
Resources:
Certificate of Analysis / MSDS:
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References:
Wentholdet al (1994)
Biochemical and assembly properties of GluR6 and KA2, two members of the
kainate receptor family, determined with subunit-specific antibodies.
J.Biol.Chem. 269 1332.
Displays 26-fold and > 440-fold selectivity over kainate and NMDA receptors respectively. Neuro-protective; delays neuronal death in a global ischaemia model and cerebral infarction in a focal ischaemia model.