Chemical Name:[3R-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-5-(Acetyloxy)-3-e
thenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pent
amethyl-1H-naphtho[2,1-b]pyran-1-one
Biological Activity:
Cell-permeable activator of adenylyl cyclase. Hypotensive and
vasodilatory agent.
Merck
Index 12 2359. Awadet al (1983) Interactions of
forskolin and adenylate cyclase. J.Biol.Chem. 258 2960. Seamonet al (1983) Structure-activity relationships for activation of
adenylate cyclase by the diterpene forskolin and its derivatives. J.Med.Chem. 26
436. Bhatet al (1983) The antihypertensive and positive
inotropic diterpene forskolin: effects of structural modifications on its
activity. J.Med.Chem. 26 486. Laurenzaet al (1989)
Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with
multiple sites of action? TiPS 10 442.
“Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..”
