More Information »Cyclooxygenase (also known as COX, Prostaglandin-endoperoxide synthase, Prostaglandin G/H synthase) is expressed in cells in three isoforms. COX-1 (constitutive) and COX-2 (inducible) isoforms catalyze the rate-limiting step of prostaglandin production.

Cyclooxygenase Products

Product Name / Activity
1706 Acetaminophen
Cyclooxygenase inhibitor; may be selective for COX-3
4092 Aspirin
Cyclooxygenase inhibitor; NSAID
3786 Celecoxib
Selective cyclooxygenase-2 (COX-2) inhibitor
4454 Diclofenac sodium salt
Cyclooxygenase inhibitor; NSAID
1430 DuP 697
Cyclooxygenase-2 (COX-2) inhibitor
3871 Etodolac
Selective cyclooxygenase-2 (COX-2) inhibitor; NSAID
2776 FK 3311
Cyclooxygenase-2 (COX-2) inhibitor
4522 Flufenamic acid
Cyclooxygenase inhibitor; NSAID. Also activates TRPC6
1769 Flurbiprofen
Cyclooxygenase inhibitor
1507 FR 122047 hydrochloride
Cyclooxygenase (COX-1) inhibitor
2796 (S)-(+)-Ibuprofen
Cyclooxygenase inhibitor (COX-1 > COX-2)
1708 Indomethacin
Cyclooxygenase inhibitor (COX-1 > COX-2)
2655 Naproxen sodium
Cyclooxygenase inhibitor
4531 NCX 4040
NO-donating aspirin; anti-inflammatory and antitumor
4537 NCX 466
Cyclooxygenase-inhibiting nitric oxide donor
4112 Niflumic acid
Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist
2470 Nimesulide
Cyclooxygenase-2 (COX-2) inhibitor
0942 NS 398
Cyclooxygenase-2 (COX-2) inhibitor
0960 Piroxicam
Cyclooxygenase-1 (COX-1) inhibitor
1418 Resveratrol
Cyclooxygenase inhibitor
1550 SC 560
Cyclooxygenase-1 (COX-1) inhibitor
2895 SC 58125
Selective cyclooxygenase-2 (COX-2) inhibitor
3919 SC 236
Selective cyclooxygenase-2 (COX-2) inhibitor
1707 Sulindac
Cyclooxygenase inhibitor (following metabolism to sulindac sulfide)
2510 Talniflumate
Cyclooxygenase inhibitor. Also chloride channel blocker
2580 Tenidap
NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3
4206 Valdecoxib
Selective and potent COX-2 inhibitor
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