Hedgehog Signaling

More Information »The Hedgehog (Hh) signaling pathway is crucial in the development of all animals. In the embryo, it regulates morphogenesis of a variety of tissues and organs; in the adult, it controls stem cell proliferation. There are three known human Hh proteins: Shh, Dhh and Ihh.

Hedgehog Signaling Products

Inhibitors
Cat.No.	Product Name / Activity
1639	AY 9944 dihydrochloride
	Inhibitor of Hedgehog (Hh) signaling. Inhibits Δ⁷-dehydrocholesterol reductase
4529	Ciliobrevin A
	Hedgehog (Hh) pathway antagonist; inhibits ciliogenesis
1623	Cyclopamine
	Inhibitor of Hedgehog (Hh) signaling
3889	GANT 58
	GLI1 antagonist; inhibits Hedgehog (Hh) signaling
3191	GANT 61
	GLI antagonist; inhibits Hedgehog (Hh) signaling
3839	HPI 1
	Inhibits Hedgehog signaling
4717	Jervine
	Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo
3341	JK 184
	Downstream Hedgehog (Hh) signaling pathway inhibitor; inhibits alcohol dehydrogenase 7
4585	MRT 10
	Smoothened (Smo) antagonist
1974	SANT-1
	Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity
3617	SANT-2
	Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity
4662	SMANT hydrochloride
	Inhibits Smoothened (Smo) accumulation
1638	U 18666A
	Inhibitor of Hedgehog (Hh) signaling. Also inhibits cholesterol synthesis
Activators
Cat.No.	Product Name / Activity
4474	20(S)-Hydroxycholesterol
	Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation
Other
Cat.No.	Product Name / Activity
3267	Thiostrepton
	Downregulates FOXM1