Phosphatases catalyze dephosphorylation. They are hydrolase enzymes that replace a phosphate group on the substrate with a hydroxyl group from water. The action of phosphatases are in direct opposition to those of kinases and phosphorylases. Dephosphorylation can activate or deactivate the substrate and enable or disable protein-protein interactions, thus they have an integral role in signal transduction pathways.
Phosphatase Target Files
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Potent, selective LRRK2 inhibitor
Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.