R&D Systems Inc. Tocris Bioscience Boston Biochem

MAPK Family

MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions.

MAPK Family Target Files

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View MAPK pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

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Six groups of MAPK have so far been identified:

  1. Extracellular signal-regulated kinases (ERK1, ERK2).
  2. c-Jun N-terminal kinases (JNKs)
  3. p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14)
  4. ERK5 (MAPK7)
  5. ERK3 (MAPK6) and ERK4 (MAPK4)
  6. ERK7/8 (MAPK15)

ERK 1 and ERK 2 transduce signals from growth factors and are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and 2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38 MAPKs (α-, β-, δ and γ- isoforms) are activated by UV irradiation, inflammatory cytokines and hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and inflammation (p38).

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Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

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Kinases Product Listing

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Immunology Guide

Immunology Research Guide

Highlights over 150 products for immunology research. Request a copy or view PDF today.

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Pain Research Product Guide

Pain Research Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

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MAPK Signaling Review

MAPK Signaling Review

Written by Elma Zaganjor and Melanie H. Cobb, leading experts. Request a copy or view PDF today.

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Learning and Memory

Written by Clea Warburton and Zafar Bashir

Learning and Memory Poster

An overview of the cellular mechanisms underlying recognition memory and its links to long-term depression. Request a copy or view PDF today.

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Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Poster

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development.

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Calcium Imbalance and Neuroprotective Targets

Written by E. Besancon et al

Neuroprotection Poster

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.

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VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.

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New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

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Bio-Techne Events

FEBS-EMBO 2014 Meeting

FEBS-EMBO 2014

August 30 - September 4, 2014

Paris, France

Booth Number: 22