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Cholecystokinin Receptors
Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. It is released simultaneously from intestinal cells and neurons in response to a meal. The precursor molecule prepro-CCK can be cleaved to generate a variety of biologically active forms of CCK including CCK-33, CCK-8 (CCK octapeptide), CCK-39 and CCK-58. Two CCK receptor subtypes, CCK1 and CCK2, mediate the physiological actions of CCK and the related peptide gastrin. The CCK1 receptor has a high affinity for sulfated CCK analogs, whereas the CCK2 receptor has similar affinity for sulfated and non-sulfated forms.
Cholecystokinin Receptor Target Files
Related Categories
| Receptor Subtype | CCK1 Receptors | CCK2 Receptors |
|---|
| Transduction Mechanism | Gq/11, Gs | Gs |
| Primary Locations | Pancreas, gall bladder, intestines, vagus nerve | Brain, spinal cord, stomach |
| Tissue Functions | Modulates food intake, pancreatic exocrine secretion and growth, gall bladder contraction, GI motility | Modulates anxiety, nociception, neuroleptic activity, gastric acid release, gastric mucosal cell growth and histamine release |
| Endogenous Ligand Potency | CCK octapeptide, sulfated >> gastrin = CCK octapeptide, non-sulfated | Gastrin = CCK octapeptide, sulfated = CCK octapeptide, non-sulfated |
| Selective Agonists | A-71623 (2411) | Gastrin I (human) (3006) |
| Selective Antagonists |
Devazepride (2304) SR 27897 (2190) |
LY 225910 (1018) YM 022 (1408) LY 288513 (1524) CI 988 (2607) PD 135158 (2608) |
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Peptide Hormone Receptors Product Listing
Highlights over 200 products for peptide hormone receptors. Reserve your free copy today and be amongst the first to receive it.
Appetite Modulation
Written by Sonia A. Tucci, Lynsay Kobelis & Tim Kirkham. Request a copy or view PDF today.
Gut Hormones and the Regulation of Appetite
Written by V.J. Taylor et al
'Gut Hormones and the Regulation of Appetite' summarizes the neuropeptide modulators and gut hormones that influence appetite
7-TM Receptor Signaling
Written by T. Kenakin et al
'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy
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