Amyloid β Peptides

More Information »Amyloid β (Aβ) peptides are the major component of amyloid plaques found in the brains of Alzheimer's patients. Aβ is formed from the progressive cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Two Aβ peptides are formed from APP degradation.

Amyloid β Peptide Products

Inhibitors
Cat.No.	Product Name / Activity
4283	Begacestat
	γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
2870	BMS 299897
	γ-secretase inhibitor; reduces Aβ levels
3360	CGP 52411
	Inhibits Aβ42 fibril formation. Also EGFR inhibitor
2442	CGP 53353
	Inhibitor of de novo Aβ42 assembly
2654	Compound W
	γ-secretase inhibitor; reduces Aβ42 levels
2634	DAPT
	γ-secretase inhibitor; reduces Aβ42 levels
4524	EGCG
	Inhibits formation of amyloid fibrils
4495	Flurizan
	γ-secretase inhibitor; lowers Aβ42 levels in vitro
2677	JLK 6
	Inhibitor of γ-secretase-mediated βAPP processing
2627	L-685,458
	Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42
4000	MRK 560
	γ-secretase inhibitor; attenuates amyloid plaque deposition
2408	Ro 90-7501
	Inhibitor of Aβ42 fibril formation
Other
Cat.No.	Product Name / Activity
3391	Amyloid β-peptide (42-1) (human)
	Inactive control peptide for amyloid β-peptide (1-42) (Cat. No. 1428)
1892	Amyloid β-Peptide (10-20) (human)
	Amyloid β-peptide; substrate for MMP-2
1894	Amyloid β-Peptide (12-28) (human)
	Amyloid β-peptide; minimum required for binding to brain proteins
1191	Amyloid β-Peptide (1-40) (human)
	Amyloid β-protein fragment
2424	Amyloid β-peptide (1-40) (rat)
	Amyloid β-protein fragment
1428	Amyloid β-Peptide (1-42) (human)
	Predominant amyloid β-protein fragment
2425	Amyloid β-peptide (1-42) (rat)
	Predominant amyloid β-protein fragment
1938	Amyloid β-Peptide (1-43) (human)
	Amyloid β-protein fragment
1429	Amyloid β-peptide (25-35) (human)
	Human amyloid β-protein fragment functionally required for neurotoxicity
3945	Colivelin
	Neuroprotective peptide; protects against β-amyloid neurotoxicity
3713	Cryptotanshinone
	Reduces Aβ generation. Also displays multiple other activities
3201	Dimebon dihydrochloride
	Neuroprotectant; protects against β-amyloid neurotoxicity
3144	K 114
	Amyloid fibril-specific fluorescent dye
4084	LPYFD-NH₂
	Binds Aβ; protects from aggregation induced toxicity
3619	Tramiprosate
	Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog
1634	Y-29794 oxalate
	Inhibitor of prolyl endopeptidase; prevents amyloid β-peptide-like deposition in vivo