R&D Systems Inc. Tocris Bioscience Boston Biochem

Amyloid β Peptides

More Information »Amyloid β (Aβ) peptides are the major component of amyloid plaques found in the brains of Alzheimer's patients. Aβ is formed from the progressive cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Two Aβ peptides are formed from APP degradation.

Amyloid β Peptide Products

Inhibitors
Cat.No.
Product Name / Activity
4283 Begacestat
γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
2870 BMS 299897
γ-secretase inhibitor; reduces Aβ levels
4924 CEP 1347
Neuroprotective; blocks Aβ-induced cortical neuron apoptosis. Also inhibitor of JNK signaling
3360 CGP 52411
Inhibits Aβ42 fibril formation. Also EGFR inhibitor
2442 CGP 53353
Inhibitor of de novo Aβ42 assembly
2654 Compound W
γ-secretase inhibitor; reduces Aβ42 levels
2634 DAPT
γ-secretase inhibitor; reduces Aβ42 levels
4524 EGCG
Inhibits formation of amyloid fibrils
4495 Flurizan
γ-secretase inhibitor; lowers Aβ42 levels in vitro
2677 JLK 6
Inhibitor of γ-secretase-mediated βAPP processing
2627 L-685,458
Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42
4000 MRK 560
γ-secretase inhibitor; attenuates amyloid plaque deposition
2408 Ro 90-7501
Inhibitor of Aβ42 fibril formation
4426 Tanshinone IIA
Inhibits Aβ aggregation; inhibits NF-κB and AP-1 DNA binding
Other
Cat.No.
Product Name / Activity
3391 Amyloid β-peptide (42-1) (human)
Inactive control peptide for amyloid β-peptide (1-42) (Cat. No. 1428)
1892 Amyloid β-Peptide (10-20) (human)
Amyloid β-peptide; substrate for MMP-2
1894 Amyloid β-Peptide (12-28) (human)
Amyloid β-peptide; minimum required for binding to brain proteins
1191 Amyloid β-Peptide (1-40) (human)
Amyloid β-protein fragment
2424 Amyloid β-peptide (1-40) (rat)
Amyloid β-protein fragment
1428 Amyloid β-Peptide (1-42) (human)
Predominant amyloid β-protein fragment
2425 Amyloid β-peptide (1-42) (rat)
Predominant amyloid β-protein fragment
1938 Amyloid β-Peptide (1-43) (human)
Amyloid β-protein fragment
1429 Amyloid β-peptide (25-35) (human)
Human amyloid β-protein fragment functionally required for neurotoxicity
3945 Colivelin
Neuroprotective peptide; protects against β-amyloid neurotoxicity
4803 CRANAD 2
Near-infrared probe that detects Aβ40 aggregates
3713 Cryptotanshinone
Reduces Aβ generation. Also displays multiple other activities
3201 Dimebon dihydrochloride
Neuroprotectant; protects against β-amyloid neurotoxicity
5081 J 147
Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
3144 K 114
Amyloid fibril-specific fluorescent dye
4084 LPYFD-NH2
Binds Aβ; protects from aggregation induced toxicity
4920 Methoxy-X04
Fluorescent amyloid β detector; brain penetrant
3619 Tramiprosate
Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog
1098 Tranilast
Antiallergic; binds to Aβ40 monomers
1634 Y-29794 oxalate
Inhibitor of prolyl endopeptidase; prevents amyloid β-peptide-like deposition in vivo
Related Categories

Quick Order

Find multiple products by catalog number

divider line

The Neurobiology of Alzheimer's Disease

Written by Alan Palmer

Alzheimer's Poster

'The Neurobiology of Alzheimer's Disease' summarizes structural and functional changes observed in the progression of AD.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

Bio-Techne Events

Purines 2014

Purines 2014

July 23 - 27, 2014

Bonn University, Germany