Amyloid β Peptides

More Information »Amyloid β (Aβ) peptides are the major component of amyloid plaques found in the brains of Alzheimer's patients. Aβ is formed from the progressive cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Two Aβ peptides are formed from APP degradation.

Amyloid β Peptide Products

Product Name / Activity
4283 Begacestat
γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
2870 BMS 299897
γ-secretase inhibitor; reduces Aβ levels
4924 CEP 1347
Neuroprotective; blocks Aβ-induced cortical neuron apoptosis. Also inhibitor of JNK signaling
3360 CGP 52411
Inhibits Aβ42 fibril formation. Also EGFR inhibitor
2442 CGP 53353
Inhibitor of de novo Aβ42 assembly
2654 Compound W
γ-secretase inhibitor; reduces Aβ42 levels
2634 DAPT
γ-secretase inhibitor; reduces Aβ42 levels
4524 EGCG
Inhibits formation of amyloid fibrils
4495 Flurizan
γ-secretase inhibitor; lowers Aβ42 levels in vitro
2677 JLK 6
Inhibitor of γ-secretase-mediated βAPP processing
2627 L-685,458
Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42
4000 MRK 560
γ-secretase inhibitor; attenuates amyloid plaque deposition
2408 Ro 90-7501
Inhibitor of Aβ42 fibril formation
4699 SEN 1269
Amyloid-β aggregation inhibitor
4426 Tanshinone IIA
Inhibits Aβ aggregation; inhibits NF-κB and AP-1 DNA binding
Product Name / Activity
5053 AC 186
Decreases Aβ levels in combination with ACP-105; ERβ agonist
3391 Amyloid β-peptide (42-1) (human)
Inactive control peptide for amyloid β-peptide (1-42) (Cat. No. 1428)
1892 Amyloid β-Peptide (10-20) (human)
Amyloid β-peptide; substrate for MMP-2
1894 Amyloid β-Peptide (12-28) (human)
Amyloid β-peptide; minimum required for binding to brain proteins
1191 Amyloid β-Peptide (1-40) (human)
Amyloid β-protein fragment
2424 Amyloid β-peptide (1-40) (rat)
Amyloid β-protein fragment
1428 Amyloid β-Peptide (1-42) (human)
Predominant amyloid β-protein fragment
2425 Amyloid β-peptide (1-42) (rat)
Predominant amyloid β-protein fragment
1938 Amyloid β-Peptide (1-43) (human)
Amyloid β-protein fragment
1429 Amyloid β-peptide (25-35) (human)
Human amyloid β-protein fragment functionally required for neurotoxicity
3945 Colivelin
Neuroprotective peptide; protects against β-amyloid neurotoxicity
4803 CRANAD 2
Near-infrared probe that detects Aβ40 aggregates
3713 Cryptotanshinone
Reduces Aβ generation. Also displays multiple other activities
3201 Dimebon dihydrochloride
Neuroprotectant; protects against β-amyloid neurotoxicity
5081 J 147
Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
3144 K 114
Amyloid fibril-specific fluorescent dye
4084 LPYFD-NH2
Binds Aβ; protects from aggregation induced toxicity
4920 Methoxy-X04
Fluorescent amyloid β detector; brain penetrant
3619 Tramiprosate
Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog
1098 Tranilast
Antiallergic; binds to Aβ40 monomers
1634 Y-29794 oxalate
Inhibitor of prolyl endopeptidase; prevents amyloid β-peptide-like deposition in vivo
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