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Voltage-gated Sodium (Na_V) Channels

More Information »Voltage-gated sodium channels (Na_V) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.

Voltage-gated Sodium (Na_V) Channel Products

Activators
Cat.No.	Product Name / Activity
2918	Veratridine
	Voltage-gated Na+ channel opener
Blockers
Cat.No.	Product Name / Activity
2976	A 803467
	Selective NaV1.8 blocker
4249	A 887826
	Potent voltage-dependent NaV1.8 channel blocker
2404	Ambroxol hydrochloride
	Na+ channel blocker
0890	Amiloride hydrochloride
	Na+ channel blocker. Also I2 imidazoline ligand
4098	Carbamazepine
	Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant
2642	Co 102862
	State-dependent Na+ channel blocker; anticonvulsant
1470	Flecainide acetate
	Cardiac Na+ channel blocker. Antiarrhythmic
0522	Flunarizine dihydrochloride
	Dual Na+/Ca2+ channel (T-type) blocker
4718	Huwentoxin IV
	Selective NaV 1.7 channel blocker
3251	KC 12291 hydrochloride
	Orally active atypical Na+ blocker; cardioprotective
3865	Licarbazepine
	Active metabolite of oxcarbazepine (Cat. No. 3684)
3057	Lidocaine
	Na+ channel blocker
2596	Mexiletine hydrochloride
	Na+ channel blocker, antiarrhythmic agent
3864	Oxcarbazepine
	Anticonvulsant; inhibits Na+ channel activity
4665	ProTx I
	CaV3.1 channel blocker; also inhibits NaV1.8 and KV2.1
4023	ProTx II
	Potent and selective NaV1.7 channel blocker
1043	QX 222
	Na+ channel blocker
1014	QX 314 bromide
	Na+ channel blocker
2313	QX 314 chloride
	Na+ channel blocker
4029	Ralfinamide mesylate
	Na+ channel blocker
0768	Riluzole hydrochloride
	Na+ channel blocker
4044	Sipatrigine
	NaV blocker; neuroprotective
4435	TC-N 1752
	Selective NaV1.7 blocker
1078	Tetrodotoxin
	Na+ channel blocker
1069	Tetrodotoxin citrate
	Na+ channel blocker. Citrate salt of tetrodotoxin (Cat. No. 1078)
0757	Vinpocetine
	Na+ channel blocker
Other
Cat.No.	Product Name / Activity
1539	β-Pompilidotoxin
	Slows neuronal Na+ channel inactivation
3828	Rufinamide
	Prolongs inactivation of sodium channels; anticonvulsant

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